DNA replication and cancer: From dysfunctional replication origin activities to therapeutic opportunities

Seminars in Cancer Biology
Anne-Sophie BoyerClaus Storgaard Sørensen

Abstract

A dividing cell has to duplicate its DNA precisely once during the cell cycle to preserve genome integrity avoiding the accumulation of genetic aberrations that promote diseases such as cancer. A large number of endogenous impacts can challenge DNA replication and cells harbor a battery of pathways to promote genome integrity during DNA replication. This includes suppressing new replication origin firing, stabilization of replicating forks, and the safe restart of forks to prevent any loss of genetic information. Here, we describe mechanisms by which oncogenes can interfere with DNA replication thereby causing DNA replication stress and genome instability. Further, we describe cellular and systemic responses to these insults with a focus on DNA replication restart pathways. Finally, we discuss the therapeutic potential of exploiting intrinsic replicative stress in cancer cells for targeted therapy.

References

Mar 5, 1976·Journal of Molecular Biology·N P HigginsB Strauss
Aug 25, 1994·Nucleic Acids Research·Y HabrakenS Prakash
Oct 9, 1998·The Journal of Biological Chemistry·H SunN Maizels
Jan 23, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Olivier HyrienArach Goldar
Apr 30, 2003·Molecular Cell·Cyrus VaziriAnindya Dutta
Apr 30, 2003·Molecular Cell·Judith Henry-MowattKeith W Caldecott
Mar 3, 2004·Nature Reviews. Cancer·Bin-Bing S Zhou, Jiri Bartek
May 26, 2004·The Journal of Cell Biology·Marina MelixetianKristian Helin
Jun 16, 2004·The Journal of Cell Biology·Susanna Ekholm-ReedSteven I Reed
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·David CortezStephen J Elledge
Sep 3, 2004·Nature Reviews. Cancer·Mats Ljungman, David P Lane
Jan 22, 2005·Nature Reviews. Cancer·Michael A GonzalezNicholas Coleman
Apr 20, 2005·Oncogene·Harry C Hwang, Bruce E Clurman
Jul 9, 2005·Trends in Biochemical Sciences·Tatsuro S TakahashiJohannes C Walter
Aug 2, 2005·Molecular and Cellular Biology·Anja Duursma, Reuven Agami
Dec 13, 2005·Nature Reviews. Molecular Cell Biology·Errol C Friedberg
Feb 3, 2006·Nature·Ryan C Heller, Kenneth J Marians
Mar 31, 2006·Nature·Susana GonzalezManuel Serrano
Jun 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stephen E MoyerMichael R Botchan
Jul 13, 2006·Journal of Cell Science·Yasutoshi TatsumiMasatoshi Fujita
Oct 5, 2006·International Journal of Cancer. Journal International Du Cancer·Zehan ChenHaiying Zhang

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Citations

Apr 27, 2016·Seminars in Cancer Biology·Alexandros G Georgakilas, Vassilis G Gorgoulis
Jul 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rodrigo Pinheiro AraldiRita de Cassia Stocco
Feb 14, 2020·Cancers·Eva MalacariaPietro Pichierri
Dec 13, 2018·Frontiers in Genetics·Zhi LiuYixue Li
Jul 16, 2020·Nature Communications·Betheney R PennycookRobertus A M de Bruin
Dec 30, 2020·Technology in Cancer Research & Treatment·Zhibin JingZheng Liang
Nov 24, 2016·Biophysical Chemistry·Vaclav UrbanPavel Janscak

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