PMID: 3763398Sep 11, 1986Paper

DNA replication and UV-induced DNA repair synthesis in human fibroblasts are much less sensitive than DNA polymerase alpha to inhibition by butylphenyl-deoxyguanosine triphosphate

Nucleic Acids Research
S L Dresler, M G Frattini

Abstract

In mammalian cells, both semiconservative DNA replication and the DNA repair patch synthesis induced by high doses of ultraviolet radiation are known to be inhibited by aphidicolin, indicating the involvement in these processes of one or both of the aphidicolin-sensitive DNA polymerases, alpha and/or delta. In this paper, N2-(p-n-butylphenyl)-2'-deoxyguanosine-5'-triphosphate, a strong inhibitor of polymerase alpha and a weak inhibitor of polymerase delta, is used to further characterize the DNA polymerase(s) involved in these two forms of nuclear DNA synthesis. In permeable human fibroblasts, DNA replication and ultraviolet-induced DNA repair synthesis are more resistant to the inhibitor than DNA polymerase alpha by factors of approximately 500 and 3000, respectively. These findings are most consistent with the involvement of DNA polymerase delta in these processes.

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Citations

May 1, 1990·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K M DowneyA G So
Feb 1, 1993·Journal of Cellular Biochemistry·F D CoffmanS Cohen
Jun 1, 1988·Human Genetics·J C LeonardK H Thompson
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Apr 13, 2005·Biochemistry. Biokhimii︠a︡·N P Sharova
Aug 1, 1988·Molecular and Cellular Biology·J HauserK Dixon

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