DNA replication factor C1 mediates genomic stability and transcriptional gene silencing in Arabidopsis.

The Plant Cell
Qian LiuZhizhong Gong

Abstract

Genetic screening identified a suppressor of ros1-1, a mutant of REPRESSOR OF SILENCING1 (ROS1; encoding a DNA demethylation protein). The suppressor is a mutation in the gene encoding the largest subunit of replication factor C (RFC1). This mutation of RFC1 reactivates the unlinked 35S-NPTII transgene, which is silenced in ros1 and also increases expression of the pericentromeric Athila retrotransposons named transcriptional silent information in a DNA methylation-independent manner. rfc1 is more sensitive than the wild type to the DNA-damaging agent methylmethane sulphonate and to the DNA inter- and intra- cross-linking agent cisplatin. The rfc1 mutant constitutively expresses the G2/M-specific cyclin CycB1;1 and other DNA repair-related genes. Treatment with DNA-damaging agents mimics the rfc1 mutation in releasing the silenced 35S-NPTII, suggesting that spontaneously induced genomic instability caused by the rfc1 mutation might partially contribute to the released transcriptional gene silencing (TGS). The frequency of somatic homologous recombination is significantly increased in the rfc1 mutant. Interestingly, ros1 mutants show increased telomere length, but rfc1 mutants show decreased telomere length and reduced expressio...Continue Reading

References

Sep 1, 1995·Molecular and Cellular Biology·G CullmannB Stillman
Sep 1, 1996·Molecular and Cellular Biology·A K Adams, C Holm
Mar 9, 1999·The Plant Journal : for Cell and Molecular Biology·S J Clough, A F Bent
May 18, 1999·Biochemical and Biophysical Research Communications·F UchiumiS i Tanuma
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·M S FitzgeraldD E Shippen
Feb 22, 2001·Science·R D WoodT Lindahl
Apr 5, 2001·Molecular and Cellular Biology·J S HannaF A Spencer
Feb 12, 2002·Nature Genetics·Jan M LuchtBarbara Hohn
Aug 8, 2002·Proceedings of the National Academy of Sciences of the United States of America·Zhizhong GongJian-Kang Zhu
Sep 19, 2002·Protein Science : a Publication of the Protein Society·Ceslovas VenclovasMichael P Thelen
Jan 2, 2003·The Plant Cell·Valérie GarciaAlain Tissier
Feb 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Vladimir P BermudezAziz Sancar
Feb 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jerzy Majka, Peter M J Burgers
Mar 5, 2003·The Plant Cell·Maria Eugenia GallegoCharles I White
Aug 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Shay Ben-AroyaMartin Kupiec
Aug 13, 2003·The EMBO Journal·Mohammed BellaouiGrant W Brown
Sep 19, 2003·Current Biology : CB·Pamela KanellisDaniel Durocher
Jan 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sarit SmolikovAnat Krauskopf
Apr 13, 2004·The Plant Cell·Kevin CulliganAnne Britt
Jun 24, 2004·Progress in Nucleic Acid Research and Molecular Biology·Jerzy Majka, Peter M J Burgers
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Wuxing LiBernd Reiss
Aug 10, 2004·Chromosoma·Magali Toueille, Ulrich Hübscher
Oct 8, 2004·The Plant Journal : for Cell and Molecular Biology·Michael WalterJörg Kudla
Apr 9, 2005·Critical Reviews in Biochemistry and Molecular Biology·Parie Garg, Peter M J Burgers
Sep 1, 2005·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Maria E Gallego, Charles I White
Sep 16, 2005·FEBS Letters·Avnish KapoorJian-Kang Zhu
Jan 27, 2006·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Tatsuya OnoKei-ichi Shibahara
Feb 3, 2006·The Journal of Biological Chemistry·Nicole SchönrockLars Hennig
Apr 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Teresa Morales-RuizTeresa Roldán-Arjona

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Citations

Jun 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Xiaojie LiZhizhong Gong
Dec 1, 2012·Cold Spring Harbor Symposia on Quantitative Biology·H Zhang, J-K Zhu
Feb 6, 2014·Journal of Experimental Botany·Cécile RaynaudMoussa Benhamed
Sep 24, 2013·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Tingxiu YaoZhizhong Gong
Jan 15, 2011·Current Opinion in Plant Biology·Qian Liu, Zhizhong Gong
Dec 17, 2010·Current Opinion in Plant Biology·Ian J Furner, Marjori Matzke
Nov 7, 2016·Current Opinion in Plant Biology·Crisanto GutierrezJoana Sequeira-Mendes
Mar 18, 2017·Genetics and Molecular Biology·Juliana Nogueira BrasilAdriana S Hemerly
Feb 7, 2018·The Plant Journal : for Cell and Molecular Biology·Jie QianJie Zhao
Sep 25, 2019·International Journal of Molecular Sciences·Jara Teresa Parrilla-DoblasDolores Córdoba-Cañero
May 9, 2019·Proceedings of the National Academy of Sciences of the United States of America·Lishuan WangZhizhong Gong
May 28, 2016·The Plant Journal : for Cell and Molecular Biology·Jixiang ZhangZhizhong Gong
Oct 2, 2019·International Journal of Molecular Sciences·Jose-Antonio Pedroza-GarciaCécile Raynaud
Nov 26, 2020·Genome Biology·Pierre BourguetOlivier Mathieu

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