DNA replication stress: from molecular mechanisms to human disease

Chromosoma
Sergio Muñoz, Juan Méndez

Abstract

The genome of proliferating cells must be precisely duplicated in each cell division cycle. Chromosomal replication entails risks such as the possibility of introducing breaks and/or mutations in the genome. Hence, DNA replication requires the coordinated action of multiple proteins and regulatory factors, whose deregulation causes severe developmental diseases and predisposes to cancer. In recent years, the concept of "replicative stress" (RS) has attracted much attention as it impinges directly on genomic stability and offers a promising new avenue to design anticancer therapies. In this review, we summarize recent progress in three areas: (1) endogenous and exogenous factors that contribute to RS, (2) molecular mechanisms that mediate the cellular responses to RS, and (3) the large list of diseases that are directly or indirectly linked to RS.

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Citations

Mar 4, 2017·Genes·Anna E Herlihy, Robertus A M de Bruin
Mar 31, 2017·Current Genetics·Hisao MasaiSeiji Matsumoto
Jul 1, 2018·The Journal of Biological Chemistry·Sara Rodriguez-AcebesJuan Méndez
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Jun 3, 2021·International Journal of Molecular Sciences·Hui Zhang
Jun 16, 2021·The EMBO Journal·Daniel González-AcostaJuan Méndez
May 17, 2021·DNA Repair·Yo-Chuen Lin, Supriya G Prasanth
Sep 1, 2021·Cellular and Molecular Life Sciences : CMLS·Kazumasa Yoshida, Masatoshi Fujita

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Methods Mentioned

BETA
electron microscopy
electrophoresis

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