PMID: 2484581Jul 1, 1989Paper

DNA sequence analysis of bacterial toxic heavy metal resistances

Biological Trace Element Research
S SilverR A Laddaga

Abstract

Bacterial plasmids have genes that confer highly specific resistances to As, Bi, Cd, Cu, Cr, Hg, Pb, Te, Zn, and other toxic heavy metals. For each toxic cation or anion, generally a different resistance system exists, and these systems may be "linked" together on multiple resistance plasmids. For Cd2+, AsO2-, AsO4(3)-, Hg2+, and organomercurials, DNA sequence analysis has supplemented direct physiological and biochemical experiments to produce sophisticated understanding. The cadA ATPase of S. aureus plasmids is a 727 amino acid membrane ATPase that pumps Cd2+ from the cells as rapidly as it is accumulated. This polypeptide is related by sequence to other cation translocating ATPases, including the membrane K+ ATPases of Escherichia coli and Streptococcus faecalis, the H+ ATPases of yeast and Neurospora, the Na+/K+ ATPases of vertebrate animals, and the Ca2+ ATPases of rabbit muscle. The conserved residues include the aspartyl residue that is phosphorylated, the lysine involved in ATP binding, and the proline within a membrane translocating region. The arsenate and arsenite translocating ATPase consists of 3 polypeptides (from DNA sequence analysis), including a recognizable ATP binding protein (arsA), an integral membrane pro...Continue Reading

References

May 11, 1978·Nature·G E SchulzE F Pai
Dec 1, 1978·Antimicrobial Agents and Chemotherapy·A A WeissT G Kinscherf
Feb 1, 1989·Trends in Biochemical Sciences·S SilverT K Misra
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G NuciforaS Silver
Jan 1, 1987·Critical Reviews in Microbiology·T J Foster
Sep 1, 1985·Journal of Bacteriology·T J Foster, N L Brown
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·H G GriffinT K Misra
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R A LaddagaS Silver
Jan 1, 1988·Annual Review of Microbiology·S Silver, T K Misra
Jan 1, 1987·Journal of Molecular Evolution·D F Feng, R F Doolittle
Feb 1, 1988·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C T WalshG L Verdine
Jan 1, 1986·Annual Review of Microbiology·A O Summers
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T K MisraS Silver
Jan 1, 1984·Annual Review of Biochemistry·C O Pabo, R T Sauer
Aug 1, 1983·Journal of Bacteriology·N N Ni'BhriainT J Foster
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S Silver, D Keach
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·H L Mobley, B P Rosen
Nov 15, 1981·Journal of Molecular Biology·R ThiemeG E Schulz

❮ Previous
Next ❯

Citations

Nov 16, 2012·PloS One·Elizabeth Lira-SilvaRicardo Jasso-Chávez
Jun 28, 2003·FEMS Microbiology Reviews·Dietrich H Nies
Dec 1, 1992·Molecular & General Genetics : MGG·R Sedlmeier, J Altenbuchner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.