DNA sequence analysis of varicella-zoster virus gene 62 from subclinical infections in healthy children immunized with the Oka varicella vaccine

Vaccine
Yasuyuki GomiMichiaki Takahashi

Abstract

A live attenuated varicella vaccine, the Oka vaccine strain (vOka), is routinely administered to children in Japan and other countries, including the United States. vOka consists of a mixture of genotypically distinct variants, but little is known about the growth potential of each variants in vivo. We isolated varicella-zoster virus (VZV) DNA sequences from the peripheral blood mononuclear cells (PBMCs) of asymptomatic healthy children immunized with the Oka varicella vaccine. VZV gene 62 DNA fragments were detected in 5 of 166 (3.0%) PBMC samples by nested PCR within 5 weeks of the vaccination. Sequence analysis of VZV DNA from these five PBMC samples indicated that multiple viral clones in the vaccine could infect vaccinees and replicate in vivo. We also provide evidence that a nonsynonymous substitution at position 105356 may affect viral replication in vivo.

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Citations

Aug 28, 2009·Journal of Clinical Microbiology·A SauerbreiP Wutzler
Sep 17, 2011·Expert Review of Vaccines·Mark QuinlivanD Scott Schmid
Mar 14, 2013·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Takao Ozaki
Apr 2, 2014·Reviews in Medical Virology·Mark Quinlivan, Judy Breuer
May 13, 2011·Clinical and Vaccine Immunology : CVI·Sonja ThieleBernhard Ehlers
Nov 23, 2018·Journal of Cutaneous Medicine and Surgery·Kim A PappJohn Wade
Feb 2, 2013·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·Takao OzakiKeiji Funahashi
Aug 17, 2016·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·Takao OzakivYoshinobu Okuno
Jun 14, 2021·Pediatric Transplantation·Daisuke TamuraTakanori Yamagata

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