DNA single strand breaks in peripheral lymphocytes associated with urinary thiodiglycolic acid levels in polyvinyl chloride workers

Mutation Research
Yu-Chen LeiTsun-Jen Cheng

Abstract

The association between vinyl chloride monomer (VCM) exposure and DNA damage has been established. However, the relationship between individual exposure and DNA single strand breaks was limited. Since environmental monitoring may not reflect the actual exposure, a useful marker of exposure is needed to assess the individual exposure. In our previous study, we have found a high correlation between air VCM level and urinary thiodiglycolic acid (TdGA) at the commencement of the next shift. Here, we further used comet assay to evaluate the relationship between urinary TdGA levels and DNA single strand breaks in polyvinyl chloride monomer (PVC) workers. Urinary TdGA levels (n=26) at the commencement of the following shift were analyzed. Ten of the 26 workers also had personal air sampling for air VCM exposure. Questionnaires were administered to obtain epidemiological information including detailed history of occupation and lifestyles. Workers experiencing air VCM level greater than 5 ppm had higher tail moment and tail intensity (%) than those experiencing VCM exposure between 1 and 5, or <1 ppm, respectively (P < 0.05). The results also revealed that level of DNA single strand breaks, including tail moment and tail intensity, were...Continue Reading

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Citations

Apr 17, 2008·Pediatric Research·Huai-Chih TsuiFang-Yang Wu
Jan 22, 2005·Environmental and Molecular Mutagenesis·Alok K PandeyAlok Dhawan
Jul 12, 2017·Journal of Applied Toxicology : JAT·Jacky Bhagat
Nov 24, 2019·The Science of the Total Environment·Ching-Chang LeeJung-Wei Chang

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