PMID: 8614561Nov 17, 1995Paper

DNA single-strand breaks in postischemic gerbil brain detected by in situ nick translation procedure

Neuroscience Letters
M TobitaK Kogure

Abstract

Using an in situ nick translation procedure, DNA single-strand breaks (SSB) in postischemic gerbil hippocampus were investigated after 15-min forebrain ischemia followed by 0-4h of recirculation. In the control group, increased SSB were noticed in the ependymal cell layer and the dentate gyrus. After 15-min ischemia without recirculation, no remarkable changes in SSB were observed. However, after 1 h of recirculation, a marked increase in SSB was recognized throughout the hippocampus, especially in the cells in CA1 subfield and the dentate gyrus. After 4 h of recirculation, SSB decreased to a level near that of the control group. The results of the present study indicate that ischemic insults may injure intranuclear DNA during postischemic recirculation periods. Although many factors may be involved, activated endonuclease due to an intracellular Ca2+ rise, free radicals, and postischemic hyperthermia appear to be involved in this phenomenon.

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Citations

Sep 29, 1999·Journal of Neuroscience Research·E W EnglanderH M Lee
Apr 3, 2012·Journal of Molecular Neuroscience : MN·Shiv S PrasadCarole Yauk
Feb 3, 2000·Free Radical Biology & Medicine·C WillyU G Plappert
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Aug 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J P MacManus, M D Linnik
Aug 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y LiN Jiang
Jun 17, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J ChenR P Simon
Jun 17, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y TuJ P MacManus
May 18, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J P MacManusU Tuor
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Oct 1, 2009·Arhiv za higijenu rada i toksikologiju·Bensu KarahalilElvin Kesimci
Nov 10, 2009·Journal of Neurochemistry·Yi ZhangDavid S Park
Jan 29, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Wen ZhangMarkus Schwaninger
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Apr 1, 1997·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·R L Martin

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