PMID: 11934013Apr 6, 2002Paper

DNA single strand breaks induced by low levels of occupational exposure to styrene: the gap between standards and reality

Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer
Magdy Y ShamySaid Khalid F El

Abstract

Styrene is a known mutagen and suspected carcinogen, used in the reinforced plastic industry. This study aims to identify the occurrence of DNA single strand breaks (SSBs) in workers exposed to styrene levels far below the recommended standards. We compared 26 exposed workers with 26 control subjects and found a significant increase in the incidence of DNA-SSBs in the exposed individuals. The levels of the biological indices of exposure (urinary mandelic and phenyl glyoxylic acids) were less than 25% of the recommended limits. Reduction of the threshold limit values/time-weighted-average (TLV-TWA) applied is strongly recommended.

Citations

May 10, 2005·Mutation Research·Leigh M Henderson, Günter Speit
Jan 16, 2007·Journal of Neurosurgery·Svetlana PravdenkovaMuhammad Husain
Sep 7, 2012·Case Reports in Otolaryngology·Shintaro SatoAkira Inokuchi

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