DNA strand breaks and crosslinks induced by transient anions in the range 2-20 eV

The Journal of Chemical Physics
Xinglan LuoL Sanche

Abstract

The energy dependence of the yields of single and double strand breaks (SSB and DSB) and crosslinks induced by electron impact on plasmid DNA films is measured in the 2-20 eV range. The yield functions exhibit two strong maxima, which are interpreted to result from the formation of core-excited resonances (i.e., transient anions) of the bases, and their decay into the autoionization channel, resulting in π → π* electronic transitions of the bases followed by electron transfer to the C-O σ* bond in the phosphate group. Occupancy of the σ* orbital ruptures the C-O bond of the backbone via dissociative electron attachment, producing a SSB. From a comparison of our results with those of other works, including theoretical calculations and electron-energy-loss spectra of the bases, the 4.6 eV peak in the SSB yield function is attributed to the resonance decay into the lowest electronically excited states of the bases; in particular, those resulting from the transitions 1(3)A'(π2 → π3*) and 1(3)A″(n2 → π3*) of thymine and 1(3)A'(π → π*) of cytosine. The strongest peak at 9.6 eV in the SSB yield function is also associated with electron captured by excited states of the bases, resulting mostly from a multitude of higher-energy π → π* t...Continue Reading

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Citations

Apr 3, 2016·The Review of Scientific Instruments·S V K KumarThupten Tsering
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Nov 13, 2021·Photochemistry and Photobiology·Chaochao LiuLéon Sanche

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Methods Mentioned

BETA
Atomic Force Microscopy
electron scattering
electron-DNA resonance
electrophoresis
AFM
electron capture
elastic

Software Mentioned

GCAT
ImageQuant

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