DNA supercoiling is a fundamental regulatory principle in the control of bacterial gene expression

Biophysics Reviews
Charles J Dorman, Matthew J Dorman

Abstract

Although it has become routine to consider DNA in terms of its role as a carrier of genetic information, it is also an important contributor to the control of gene expression. This regulatory principle arises from its structural properties. DNA is maintained in an underwound state in most bacterial cells and this has important implications both for DNA storage in the nucleoid and for the expression of genetic information. Underwinding of the DNA through reduction in its linking number potentially imparts energy to the duplex that is available to drive DNA transactions, such as transcription, replication and recombination. The topological state of DNA also influences its affinity for some DNA binding proteins, especially in DNA sequences that have a high A + T base content. The underwinding of DNA by the ATP-dependent topoisomerase DNA gyrase creates a continuum between metabolic flux, DNA topology and gene expression that underpins the global response of the genome to changes in the intracellular and external environments. These connections describe a fundamental and generalised mechanism affecting global gene expression that underlies the specific control of transcription operating through conventional transcription factors. T...Continue Reading

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Citations

Jul 10, 2019·Molecular Microbiology·Daniela KeinhörsterChristiane Wolz
Jul 6, 2019·Nucleic Acids Research·Jorge B SchvartzmanAndrzej Stasiak
Nov 27, 2018·Nucleic Acids Research·Riccardo ZiraldoStephen D Levene
Aug 23, 2018·Drug Development and Industrial Pharmacy·Sahar Youssef Al-OkbiDina Mahmoud Mostafa
Jul 16, 2020·International Journal of Molecular Sciences·Mateusz KciukRenata Kontek
Jul 20, 2019·BMC Molecular and Cell Biology·Charles J Dorman
Dec 13, 2019·PLoS Genetics·Subhash C VermaSankar L Adhya
Mar 18, 2020·Nucleic Acids Research·Massa J ShouraStephen D Levene
Dec 1, 2017·Current Genetics·Sam MeyerGeorgi Muskhelishvili
Apr 28, 2019·International Journal of Molecular Sciences·Steffi GoffartJaakko L O Pohjoismäki
Mar 14, 2019·Frontiers in Microbiology·Gregory T MarczynskiPriya Patel
Jun 20, 2019·Nucleic Acids Research·Bilal El HoudaiguiSam Meyer
Aug 28, 2019·Computational and Structural Biotechnology Journal·Shiny Martis BSam Meyer
Jan 13, 2021·Life·Patricia Fajardo-Cavazos, Wayne L Nicholson
May 1, 2021·International Journal of Molecular Sciences·Karolina KoteckaAneta Agnieszka Bartosik
Sep 30, 2021·Nature Communications·Jonathan M FoggLynn Zechiedrich

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