PMID: 641374May 1, 1978Paper

DNA synthesis among uninvolved and involved psoriatic epidermal cells and normal epidermal cells in vitro

The Journal of Investigative Dermatology
R A HarperR W Urbanek

Abstract

Epidermal cells from 8 patients with psoriasis (involved and uninvolved areas) and from 7 normal individuals, were propagated in vitro. DNA synthesis was determined autoradiographically by measuring the labeling index (1 hr) and a continuous labeling index (72 hr) on 8-10 day old cell cultures. No differences in these 2 kinetic parameters were obtained with respect to involved and uninvolved psoriatic cells. However, when psoriatic cells (involved and uninvolved) were compared to normal cells, the psoriatic cells exhibited a much higher labeling index and continuous labeling index, 200-300% and 60-70% respectively. These data clearly show that in vitro (1) epidermal cells from clinically uninvolved skin of psoriatics proliferate at a rate equal to that of involved psoriatic cells and (2) psoriatic epidermal cells proliferate at a rate greater than normal cells.

Citations

Mar 1, 1985·The British Journal of Dermatology·K KragballeC L Marcelo
Oct 1, 1983·The Journal of Dermatology·J NakayamaH Urabe
Apr 1, 1981·The Journal of Dermatology·H KatayamaA Kawada
Feb 1, 1984·Journal of Cutaneous Pathology·S Imayama, H Urabe
Jan 3, 2013·Journal of Tissue Engineering and Regenerative Medicine·Jessica JeanRoxane Pouliot
Aug 1, 1995·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·L K PershingT M Rallis
Jun 1, 1980·The Journal of Dermatology·H Urabe, K Nishitani
Sep 1, 1984·The British Journal of Dermatology·G Frentz, U Møller
Jan 1, 1980·Pharmacology & Therapeutics·C L Marcelo, J J Voorhees
Aug 12, 2004·The Journal of Investigative Dermatology·Christina SiemesVolker Herzog

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