PMID: 375021Mar 9, 1979Paper

DNA synthesis in UV-irradiated Escherichia coli K-12 strains carrying dnaA mutations

Molecular & General Genetics : MGG
P Jonczyk, Z Cieśla

Abstract

It has been found that UV irradiation of dnaA mutants of E. coli K-12 enables the initiation of DNA synthesis at a temperature restrictive to these mutants. The UV-induced DNA synthesis is dependent on protein synthesis and on a transcriptional event at a time when protein synthesis is no longer required. In contrast to dnaA mutants UV irradiation fails to induce DNA synthesis in the two other initiation mutants dnaC2 and dnaB252. DNA synthesis at the restrictive temperature is initiated also when the tif-1 phenotype is expressed in the dnaA46 tif-1 double mutant. Possible mechanisms of the observed capability of dnaA mutants to synthesize DNA at the restrictive temperature after UV irradiation or under conditions of tif-1 expression are discussed.

References

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Citations

Jan 1, 1980·Molecular & General Genetics : MGG·Z Cieśla, P Jonczyk
Aug 1, 1993·Mutation Research·M Altshuler
Mar 21, 2007·Genes & Development·Christian J RudolphRobert G Lloyd
Jul 23, 2008·DNA Repair·Christian J RudolphRobert G Lloyd
Nov 22, 2005·Journal of Molecular Biology·Elena A Kouzminova, Andrei Kuzminov
Jan 1, 1993·Critical Reviews in Biochemistry and Molecular Biology·Z LivnehT Elizur
May 30, 1998·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·M M Cox

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