PMID: 7370957Apr 15, 1980Paper

DNA synthesis of benign human breast tumors in the untreated athymic "nude" mouse. An in vivo model to study hormonal influences on growth of human breast tissues

Cancer
M J McManus, C W Welsch

Abstract

DNA synthesis in 33 human benign breast tissue biopsy specimens (HBT) was determined by 3H-thymidine radioautography 0, 15, 30, and 60 days after s.c. transplantation to female nude mice. A third of the grafts was removed from each mouse at each time period. Grafts and 0-day slices were exposed to 3H-thymidine in vitro. Labeling indices (LI) [number of radiolabeled epithelial cells per unit area epithelium (0.1 mm2)] were calculated for 0-day slices and grafts from each mouse at each time period. The LI of high 0-day HBT grafts (LI greater than 15) decreased significantly between 0 and 15 and 0 and 30 days. The LI of low 0-day HBT grafts (LI less than 15) increased significantly at 15 days then decreased to 0-day levels at 30 days. No significant differences in LI of HBT grafts were observed between 30 and 60 days. Thus, a model has been proposed for studies of factors effecting the growth of human breast tissues transplanted to nude mice in which (1) each mouse is used as its own control by measuring DNA synthesis of grafts before and after treatment, and (2) the treatment is initiated 30 days or more after transplantation of breast tissues when graft DNA synthesis is stabilized. Using this model, we have observed marked incre...Continue Reading

References

Jun 1, 1976·Journal of the National Cancer Institute·Y ShimosatoT Nomura
May 1, 1977·Journal of the National Cancer Institute·J R MastersJ J Scarisbrick
Oct 15, 1975·International Journal of Cancer. Journal International Du Cancer·C MerendaS Carrel
Dec 1, 1975·Journal of the National Cancer Institute·H C Outzen, R P Custer
Jan 1, 1973·Journal of the National Cancer Institute·B MacMahonJ Brown

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Citations

Jan 1, 1984·Virchows Archiv. A, Pathological Anatomy and Histopathology·B A GustersonJ D Dubois
Mar 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·Daniel Medina
Jan 1, 1987·Differentiation; Research in Biological Diversity·J D DuboisB A Gusterson
Jul 1, 1982·Cancer·R W BrownP S Bhathal
Dec 28, 2016·Cancer Metastasis Reviews·Lacey E DobroleckiMichael T Lewis
Mar 22, 2021·Experimental and Molecular Pathology·Juliana Cristina de SouzaCarolina Cavaliéri Gomes

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