DNA-templated organic synthesis: nature's strategy for controlling chemical reactivity applied to synthetic molecules

Angewandte Chemie
Xiaoyu Li, David R Liu

Abstract

In contrast to the approach commonly taken by chemists, nature controls chemical reactivity by modulating the effective molarity of highly dilute reactants through macromolecule-templated synthesis. Nature's approach enables complex mixtures in a single solution to react with efficiencies and selectivities that cannot be achieved in conventional laboratory synthesis. DNA-templated organic synthesis (DTS) is emerging as a surprisingly general way to control the reactivity of synthetic molecules by using nature's effective-molarity-based approach. Recent developments have expanded the scope and capabilities of DTS from its origins as a model of prebiotic nucleic acid replication to its current ability to translate DNA sequences into complex small-molecule and polymer products of multistep organic synthesis. An understanding of fundamental principles underlying DTS has played an important role in these developments. Early applications of DTS include nucleic acid sensing, small-molecule discovery, and reaction discovery with the help of translation, selection, and amplification methods previously available only to biological molecules.

Citations

Jul 12, 2013·Analytical Chemistry·Yongsheng XiaoYinsheng Wang
Jun 26, 2012·Accounts of Chemical Research·Tobias Schnitzler, Andreas Herrmann
Jul 4, 2009·Bioconjugate Chemistry·Casper S AndersenKurt V Gothelf
Nov 23, 2006·Journal of the American Chemical Society·Bo LiuThomas Kodadek
Aug 5, 2010·Journal of the American Chemical Society·Jennifer L FurmanIndraneel Ghosh
Jul 19, 2011·Journal of the American Chemical Society·Ashwani K Sharma, Jennifer M Heemstra
Jan 27, 2012·Journal of the American Chemical Society·Mireya L McKeeAndrew J Turberfield
Apr 18, 2012·Journal of the American Chemical Society·Hidekazu YamadaEiji Yashima
Aug 10, 2012·Journal of the American Chemical Society·Zhixing ChenVirginia W Cornish
Dec 11, 2013·Journal of the American Chemical Society·Tino ZdobinskyRafal Klajn
Jul 2, 2009·Journal of the American Chemical Society·John M PicuriM Reza Ghadiri
Nov 6, 2009·Journal of the American Chemical Society·Raphael M Franzini, Eric T Kool
Dec 21, 2013·The Journal of Organic Chemistry·Krishna N Ganesh, Yamuna Krishnan
Oct 15, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Tao ZhangDongsheng Liu
Dec 31, 2011·Organic Letters·Manuel RöthlingshöferNicolas Winssinger
Aug 4, 2009·Nature Chemical Biology·Matthew A ClarkBarry A Morgan
Feb 22, 2012·Nature Chemical Biology·George GeorghiouMarkus A Seeliger
Oct 12, 2010·Nature Nanotechnology·Alexandru Rotaru, Kurt V Gothelf
Jun 22, 2005·Chemical Communications : Chem Comm·Masayuki EndoTetsuro Majima
Jun 24, 2008·Chemical Society Reviews·Zbigniew L Pianowski, Nicolas Winssinger
Jan 26, 2008·Chemical Communications : Chem Comm·Zbigniew L Pianowski, Nicolas Winssinger
Nov 21, 2008·Chemical Society Reviews·XiangDong LiuNorio Nishi
Jul 4, 2008·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Robert L LetsingerFrederick D Lewis
Aug 8, 2008·Chemical Communications : Chem Comm·Jinmin FanYingfu Li
Jul 26, 2008·Chemical Communications : Chem Comm·Scott K Silverman
May 23, 2009·Chemical Communications : Chem Comm·Prabodhika MallikaratchyWeihong Tan
Oct 30, 2009·Chemical Communications : Chem Comm·Aya ShibataYoshihiro Ito
Apr 13, 2011·Chemical Communications : Chem Comm·Omid Khakshoor, Eric T Kool
Sep 3, 2011·Physical Chemistry Chemical Physics : PCCP·Kalen N SwanickZhifeng Ding
May 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Walter E KowtoniukDavid R Liu
Dec 11, 2007·Nucleosides, Nucleotides & Nucleic Acids·Ulla JakobsenStefan Vogel
Jun 19, 2013·Nucleic Acids Research·Jolita SeckuteNeal K Devaraj
Jul 15, 2004·PLoS Biology·David R Liu
May 1, 2009·HFSP Journal·Ralf JungmannFriedrich C Simmel
Mar 5, 2014·Chemical Communications : Chem Comm·Dylan W Domaille, Jennifer N Cha
Mar 29, 2014·Organic & Biomolecular Chemistry·Julia MichaelisOliver Seitz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.