DNA-testing for BRCA1/2 prior to genetic counselling in patients with breast cancer: design of an intervention study, DNA-direct.

BMC Women's Health
Aisha S SieNicoline Hoogerbrugge

Abstract

Current practice for patients with breast cancer referred for genetic counseling, includes face-to-face consultations with a genetic counselor prior to and following DNA-testing. This is based on guidelines regarding Huntington's disease in anticipation of high psychosocial impact of DNA-testing for mutations in BRCA1/2 genes. The initial consultation covers generic information regarding hereditary breast cancer and the (im)possibilities of DNA-testing, prior to such testing. Patients with breast cancer may see this information as irrelevant or unnecessary because individual genetic advice depends on DNA-test results. Also, verbal information is not always remembered well by patients. A different format for this information prior to DNA-testing is possible: replacing initial face-to-face genetic counseling (DNA-intake procedure) by telephone, written and digital information sent to patients' homes (DNA-direct procedure). In this intervention study, 150 patients with breast cancer referred to the department of Clinical Genetics of the Radboud University Nijmegen Medical Centre are given the choice between two procedures, DNA-direct (intervention group) or DNA-intake (usual care, control group). During a triage telephone call, pa...Continue Reading

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Citations

Jun 25, 2013·Journal of Genetic Counseling·Marcos Ricardo Datti MichelettoAgnes Cristina Fett-Conte
Jul 26, 2018·Journal of Medical Genetics·Jeanna M McCuaigUNKNOWN BRCA TtoT Community of Practice
May 29, 2020·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Rosie O'SheaNatalie Taylor
Dec 24, 2018·European Journal of Human Genetics : EJHG·Chris JacobsSusan Michie

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Methods Mentioned

BETA
blood drawn

Software Mentioned

SPSS

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