DNA topoisomerases and their poisoning by anticancer and antibacterial drugs

Chemistry & Biology
Yves PommierChristophe Marchand

Abstract

DNA topoisomerases are the targets of important anticancer and antibacterial drugs. Camptothecins and novel noncamptothecins in clinical development (indenoisoquinolines and ARC-111) target eukaryotic type IB topoisomerases (Top1), whereas human type IIA topoisomerases (Top2alpha and Top2beta) are the targets of the widely used anticancer agents etoposide, anthracyclines (doxorubicin, daunorubicin), and mitoxantrone. Bacterial type II topoisomerases (gyrase and Topo IV) are the targets of quinolones and aminocoumarin antibiotics. This review focuses on the molecular and biochemical characteristics of topoisomerases and their inhibitors. We also discuss the common mechanism of action of topoisomerase poisons by interfacial inhibition and trapping of topoisomerase cleavage complexes.

References

Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·M GellertH A Nash
Dec 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·M GellertJ Tomizawa
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R BertrandYves Pommier
Aug 1, 1991·Antimicrobial Agents and Chemotherapy·H YoshidaS Nakamura
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·Stewart Shuman
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L F Liu, J C Wang
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T Goto, J C Wang
Feb 14, 1971·Journal of Molecular Biology·J C Wang
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·C H Freudenreich, K N Kreuzer
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M P LeeT S Hsieh
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·R HanaiJ C Wang
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·S W YangH A Nash
Dec 1, 1996·Molecular and Cellular Biology·S G MorhamO Smithies
Sep 28, 1998·Biochimica Et Biophysica Acta·Giovanni Capranico, M Binaschi
Sep 28, 1998·Biochimica Et Biophysica Acta·Stewart Shuman
Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·R StrickJ D Rowley
Nov 30, 2000·Nucleosides, Nucleotides & Nucleic Acids·J G HeddleAnthony Maxwell
Aug 30, 2001·Proceedings of the National Academy of Sciences of the United States of America·H ZhangYves Pommier
Sep 5, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·J J PouliotH A Nash
Feb 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Berit Olsen Krogh, Stewart Shuman
Mar 6, 2002·Blood·Jens Pedersen-BjergaardClaus Nerlov
Jun 4, 2002·Nature Reviews. Molecular Cell Biology·James C Wang
Nov 12, 2002·Proceedings of the National Academy of Sciences of the United States of America·Bart L StakerLance Stewart
Jul 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Michael D StoneNicholas R Cozzarelli
Sep 1, 1962·Journal of Medicinal and Pharmaceutical Chemistry·G Y LESHERR P BRUNDAGE
Oct 2, 2003·European Journal of Biochemistry·Robert L LowDavid B Friedman
Feb 12, 2004·Eukaryotic Cell·Mobeen Malik, John L Nitiss
Apr 21, 2004·Nucleic Acids Research·Hongliang ZhangYves Pommier
May 29, 2004·Journal of Molecular Biology·Jill E ChrencikMatthew R Redinbo
Aug 17, 2005·Current Medicinal Chemistry. Anti-cancer Agents·Yves Pommier, Christophe Marchand
Sep 6, 2005·The Journal of Biological Chemistry·Heidrun InterthalJames J Champoux
May 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yves PommierKurt W Kohn
Jul 22, 2006·Annual Review of Genetics·Leonard Wu, Ian D Hickson
Jul 22, 2006·DNA Repair·Carolyn A FelixNeil Osheroff
Sep 16, 2006·The Journal of Biological Chemistry·Ailing ZhangLeroy F Liu
Sep 23, 2006·Nature Reviews. Cancer·Yves Pommier
Dec 13, 2006·Biochimie·Hongliang ZhangYves Pommier
Feb 13, 2007·Biochimie·Patrick ForterreMarie-Claude Serre
Jun 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Anna M AzarovaLeroy F Liu
Aug 19, 2007·Current Medicinal Chemistry·Marko OblakTom Solmajer
Nov 1, 2007·Infectious Disorders Drug Targets·Khisimuzi Mdluli, Zhenkun Ma
Dec 7, 2007·Biochemical Pharmacology·Beverly A Teicher
Apr 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Supaart SirikantaramasKazuki Saito
May 14, 2008·Anti-cancer Agents in Medicinal Chemistry·Thomas S DexheimerYves Pommier
Jun 17, 2008·Current Opinion in Pharmacology·Barton J Bradbury, Michael J Pucci
Jul 26, 2008·Nucleic Acids Research·Joseph E DeweeseNeil Osheroff
Aug 30, 2008·Quarterly Reviews of Biophysics·Allyn J Schoeffler, James M Berger
Dec 2, 2008·Nucleic Acids Research·Joseph E Deweese, Neil Osheroff
Dec 2, 2008·Nucleic Acids Research·Yuk-Ching Tse-Dinh
Apr 21, 2009·Nature Reviews. Cancer·John L Nitiss
Apr 21, 2009·Nature Reviews. Cancer·John L Nitiss
Apr 23, 2009·Molecular Cancer Therapeutics·Yves Pommier, Mark Cushman
May 19, 2009·Nature Structural & Molecular Biology·Ivan LaponogovMark R Sanderson
Jun 6, 2009·Annual Review of Biochemistry·James C Wang
Jul 2, 2009·Nature Reviews. Drug Discovery·Silvia Lapenna, Antonio Giordano
Sep 15, 2009·Current Topics in Medicinal Chemistry·Karl DrlicaXilin Zhao

Citations

Sep 10, 2011·Applied Microbiology and Biotechnology·Frédéric CollinAnthony Maxwell
Jul 24, 2012·Investigational New Drugs·Etchison RyanA Kratzke Robert
Dec 19, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Masahiro KatoKenichi Yoshida
Mar 27, 2013·European Journal of Medicinal Chemistry·Guyue ChengZonghui Yuan
May 21, 2011·Biochemistry·David A JacobJoseph E Deweese
Feb 7, 2012·Biochemistry·Adam C KetronNeil Osheroff
Dec 21, 2012·Biochemistry·Adam C KetronNeil Osheroff
Dec 25, 2012·ACS Chemical Biology·Yves Pommier
Apr 3, 2012·Nature Structural & Molecular Biology·S K MungamuriS A Aaronson
Apr 10, 2012·Nature Structural & Molecular Biology·Aakash BasuZev Bryant
Oct 30, 2012·Nature Structural & Molecular Biology·Ke ShiHideki Aihara
Feb 12, 2013·Nature Structural & Molecular Biology·Matteo BertiAlessandro Vindigni
Apr 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Zhongtao ZhangYuk-Ching Tse-Dinh
Feb 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sanghwa LeeSungchul Hohng
Dec 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Christophe E Redon, William M Bonner
Jun 19, 2013·Assay and Drug Development Technologies·Nikko P TorresGrant W Brown
Aug 21, 2012·Antioxidants & Redox Signaling·V Ashutosh Rao
Nov 30, 2010·Carcinogenesis·Laura M Williamson, Susan P Lees-Miller
Mar 5, 2011·Nucleic Acids Research·Johanna EddyNancy Maizels
Jun 29, 2012·Nucleic Acids Research·Zhihong ZengSherif F El-Khamisy
Jul 31, 2012·Nucleic Acids Research·Shantanu KarkareAnthony Maxwell
May 18, 2013·Nucleic Acids Research·Kevin M JudeJames M Berger
Jun 28, 2011·Science·Nayun KimSue Jinks-Robertson
Aug 8, 2012·Antimicrobial Agents and Chemotherapy·Sandra Aedo, Yuk-Ching Tse-Dinh
May 31, 2012·Molekuliarnaia biologiia·D A Giliarov, I S Shkundina
Jul 20, 2012·Biochemistry Research International·Eleftheria TsakalozouYounsoo Bae
Mar 1, 2012·Radiation Oncology·Ira K GordonKevin Camphausen
Jul 17, 2013·BMC Research Notes·Shantanu KarkareAnthony Maxwell
Aug 18, 2012·PloS One·Huarui Lu, Timothy C Hallstrom
Feb 12, 2014·Drug Design, Development and Therapy·Sarfaraz Alam, Feroz Khan
Feb 4, 2014·International Journal of Nanomedicine·Mateusz LegutJerzy Gubernator
Oct 16, 2012·International Journal of Environmental Research and Public Health·Ida CasorelliMargherita Bignami
Feb 28, 2013·International Journal of Molecular Sciences·Jirina TyleckovaHana Kovarova
Aug 10, 2013·Journal of Ayurveda and Integrative Medicine·Fazlin Mohd FauziAndreas Bender
Oct 2, 2013·International Journal of Medical Microbiology : IJMM·Lutz Heide
Sep 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yeonee SeolKeir C Neuman
Dec 4, 2013·AAPS PharmSciTech·Shahidur RahmanMichalakis Savva
Mar 29, 2014·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Adam C Ketron, Neil Osheroff
Mar 19, 2014·European Journal of Medicinal Chemistry·Lisa Dalla ViaAdriana Chilin
Mar 15, 2012·EMBO Molecular Medicine·Chris T WilliamsonSusan P Lees-Miller
Mar 19, 2013·Annual Review of Biochemistry·Stefanie Hartman ChenTao-shih Hsieh
Aug 13, 2013·Nucleic Acids Research·Christoforos NikolaouJoaquim Roca
May 3, 2014·Critical Reviews in Oncology/hematology·Rebecca L Wright, Andrew T M Vaughan
Jun 14, 2014·Cell Death and Differentiation·H-H ZhangX-D Zhang
Aug 3, 2014·Research in Veterinary Science·Joseph HillRobert Gogal
Oct 22, 2014·Proceedings of the National Academy of Sciences of the United States of America·DongYu GuoHoward A Nash
Dec 18, 2014·International Journal for Parasitology. Drugs and Drug Resistance·Rafael Balaña-FouceRosa M Reguera
Sep 18, 2013·Antimicrobial Agents and Chemotherapy·Neil R StokesDavid J Haydon
Jun 7, 2011·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yanyun XieDamu Tang
Feb 16, 2016·Cancer Letters·Nils H NicolayPeter E Huber
Jan 23, 2016·Proceedings of the National Academy of Sciences of the United States of America·Katie J AldredNeil Osheroff
Oct 16, 2015·Expert Review of Neurotherapeutics·Omar Abdel-Rahman, Mona Fouad
Dec 4, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anika Schroeter, Doris Marko
Dec 17, 2014·International Journal of Molecular Sciences·Jaromir GumulecMichal Masarik
Nov 30, 2011·The Journal of Cell Biology·Marie RegairazYves Pommier
Nov 9, 2015·International Journal of Cancer. Journal International Du Cancer·Anna WojtuszkiewiczJacqueline Cloos
Sep 23, 2014·Expert Opinion on Drug Delivery·Christopher M Knapp, Kathryn A Whitehead
Feb 18, 2016·The Journal of Cell Biology·Tomas AparicioJean Gautier
Oct 12, 2011·Expert Opinion on Investigational Drugs·Pamela N Munster, Adil I Daud
Dec 2, 2014·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·S AydinS Bico
Feb 22, 2016·Current Microbiology·Judith NaamalaFelix D Dakora
Sep 13, 2015·Cancer Science·Go J Yoshida, Hideyuki Saya
Nov 26, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Anupam DasAnjan Chakraborty
Jan 3, 2016·Toxicology Letters·S A BaechlerDoris Marko
Jun 13, 2013·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Michela Garofalo, Carlo M Croce
Nov 21, 2012·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Justin R PritchardMichael T Hemann
Oct 13, 2015·Molecular Nutrition & Food Research·Anika SchroeterDoris Marko
Nov 5, 2015·Apoptosis : an International Journal on Programmed Cell Death·Mei-Yun HuangDong-Yun Ouyang
Jul 4, 2012·Neurosurgery Clinics of North America·Yasuaki Harasaki, Allen Waziri
Apr 24, 2012·Hematology/oncology Clinics of North America·Julia Moukharskaya, Claire Verschraegen
Dec 27, 2011·Pharmacology & Therapeutics·K AzizA G Georgakilas
Sep 1, 2012·Translational Oncology·Tino KurzJan Olof G Karlsson
Aug 30, 2011·Biochemical Pharmacology·Hélène SabatelYvette Habraken
Jun 21, 2011·Biochemical and Biophysical Research Communications·Yoshifumi HosonoMasayuki Seki
May 24, 2011·European Journal of Medicinal Chemistry·Wei-Bin WuZhi-Shu Huang
Jun 26, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xin LiJianmin Li
Aug 2, 2015·International Journal of Biological Macromolecules·Sara D VieiraAlessandro Desideri
Dec 15, 2015·Nature Communications·Efrat DvashMenachem Rubinstein
Nov 23, 2015·Molecular Cell·Mark J O'Connor
Nov 13, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Wenzhuan MaPengfei Tu
Jul 29, 2015·Naunyn-Schmiedeberg's Archives of Pharmacology·Nunzio Antonio CacciolaPierlorenzo Pallante
Oct 11, 2012·Environmental and Molecular Mutagenesis·Marietta Y W T LeeErnest Y C Lee
Apr 5, 2013·European Journal of Haematology·Marieta GenchevaLaura F Gibson
Dec 5, 2013·Cell Biology International·Aneta ZabkaJanusz Maszewski
Feb 6, 2014·Annals of the New York Academy of Sciences·Maryjean PendletonNeil Osheroff
Mar 4, 2014·Molecular Nutrition & Food Research·S A BaechlerDoris Marko
Apr 6, 2016·Frontiers in Pharmacology·Guyue ChengZonghui Yuan
Mar 17, 2016·Chemical Research in Toxicology·James T WilsonJoseph E Deweese
Jul 28, 2015·Cell Cycle·Paulina RybakJurek Dobrucki
Apr 1, 2016·Journal of Experimental & Clinical Cancer Research : CR·Niels Frank JensenYves Pommier
Feb 26, 2016·Cancer Chemotherapy and Pharmacology·Charles GuenanciaCatherine Vergely
Feb 27, 2016·Nucleic Acids Research·Anand G PatelScott H Kaufmann
Aug 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Salim KhiatiYves Pommier
Dec 17, 2014·Pharmacology Research & Perspectives·Amartya MishraHemanta K Majumder
Jan 13, 2015·Environmental Microbiology·Carlos Molina-SantiagoJuan-Luis Ramos
Apr 26, 2014·Environmental Microbiology·Esteban Martínez-GarcíaVíctor de Lorenzo
Feb 11, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Suoyuan LiZhengdong Cai
Jul 16, 2015·The Journal of Antimicrobial Chemotherapy·Alina Iulia ChiriacHans-Georg Sahl
Oct 9, 2012·Biochemical Pharmacology·Brian B HasinoffJack C Yalowich
Dec 24, 2013·Biochimica Et Biophysica Acta·Fan YangSteven Henikoff
Apr 23, 2013·Journal of Molecular Biology·Markus G Rudolph, Dagmar Klostermeier
Mar 22, 2013·Biochemical Society Transactions·Ksenia TerekhovaAlfonso Mondragón
Apr 13, 2013·European Journal of Medicinal Chemistry·Qingqing HuangWei Lu
Nov 10, 2012·Critical Reviews in Clinical Laboratory Sciences·Zbigniew DarzynkiewiczDonald Wlodkowic
Aug 17, 2011·Expert Opinion on Therapeutic Patents·Shar-yin N HuangChristophe Marchand
Apr 25, 2013·Expert Opinion on Therapeutic Patents·Daulat B Khadka, Won-Jea Cho
Jul 8, 2015·Journal of Cancer Prevention·Young Ho Seo
Jun 19, 2015·Cell Death & Disease·Nina MohellKlas G Wiman
May 9, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Benjamin DemoulinPatrick Dumont
May 30, 2015·Breast Cancer Research and Treatment·Hua ZhangGeorgios Giamas
Apr 16, 2015·Future Medicinal Chemistry·Yuk-Ching Tse-Dinh
Oct 7, 2015·Current Colorectal Cancer Reports·Timothy J Zumwalt, Ajay Goel
Mar 18, 2015·Molecular Oncology·Ida Marie Heeholm SønderstrupLene Riis
Feb 20, 2015·Case Reports in Ophthalmological Medicine·Robert A PrinziUday R Desai
Feb 24, 2015·Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis·Fan YangSteven Henikoff
Oct 19, 2013·Transcription·Laura BaranelloDavid Levens
Nov 20, 2012·Cell Cycle·Yong-Wei ZhangYves Pommier
Jul 27, 2012·International Journal of Antimicrobial Agents·Joaquim RuizCláudia Gomes
Nov 5, 2013·Plant Physiology and Biochemistry : PPB·Aneta ZabkaJanusz Maszewski
Dec 8, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Venkata V V R MaradaYohannes Hagos
Jan 21, 2014·Experimental Gerontology·Stefan Sobek, Fritz Boege
Apr 23, 2013·Current Biology : CB·Fan YangSteven Henikoff
Oct 21, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yousaf Ali, Shafida Abd Hamid
Jan 26, 2013·Toxicology and Applied Pharmacology·Francisco W A BarrosCláudia Pessoa
Dec 3, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jianqin LuSong Li
Dec 3, 2014·Cell Reports·Fengtao SuAroumougame Asaithamby
May 27, 2014·DNA Repair·Yves PommierChristophe Marchand
Jun 28, 2011·Chemistry & Biology·Makoto KawataniHiroyuki Osada
Dec 18, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A Dalhoff
Mar 22, 2015·Mutation Research. Reviews in Mutation Research·M GuérardR Froetschl
Mar 20, 2014·Biochemical and Biophysical Research Communications·Adwait Anand GodboleValakunja Nagaraja
Nov 29, 2014·Frontiers in Microbiology·Terence S CroftsMichiko E Taga
Apr 26, 2016·Medicinal Research Reviews·Enas M Malik, Christa E Müller
Dec 17, 2014·Ecotoxicology and Environmental Safety·Mirco Dalla BonaMarco De Liguoro
May 29, 2016·Mutation Research. Reviews in Mutation Research·Jaqueline C RochaJenifer Saffi
Sep 21, 2013·Journal of Biomolecular Structure & Dynamics·Kyohei HanaokaKenji Shiraishi
May 26, 2016·Biophysical Journal·Ikenna D Ivenso, Todd D Lillian
Jun 11, 2016·Mechanisms of Ageing and Development·Reham AtteyaSherif F El-Khamisy
Jun 11, 2016·Future Medicinal Chemistry·Yuk-Ching Tse-Dinh
Aug 16, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Khan Behlol Ayaz AhmedAnbazhagan Veerappan
Sep 21, 2016·Journal of the American Statistical Association·Lisa M PhamEric D Kolaczyk
Jun 19, 2016·Journal of Ovarian Research·Yang BaiXin Lu
Nov 17, 2015·PloS One·Amanda E HargrovePeter B Dervan
Jun 28, 2016·Archives of Toxicology·Roberto Marques DamianiJenifer Saffi
Jun 30, 2016·The Journal of Antimicrobial Chemotherapy·Cédric CharrierNeil R Stokes
Jul 14, 2016·Nucleic Acids Research·Kevin Z L WuCorrado Santocanale
Jul 20, 2016·Archives of Biochemistry and Biophysics·Venn VuteyAlessandro Desideri
Jul 21, 2016·International Journal of Biological Macromolecules·Sinara Mônica Vitalino de AlmeidaMaria do Carmo Alves de Lima
Jul 30, 2016·Mechanisms of Ageing and Development·Bingcheng JiangMichael Weinfeld
Jul 30, 2016·Nucleic Acids Research·Ibtissam TalhaouiAlexander A Ishchenko
Jul 29, 2016·PloS One·Frank R BeierleinTimothy Clark
Jul 30, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qiaolin DongGuochang Sun
Aug 16, 2016·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Marcelo de Campos-NebelMarcela González-Cid
Sep 7, 2016·European Journal of Medicinal Chemistry·Alberto MazzaMaria Luisa Gelmi
Aug 28, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gregoire F Le BrasClaudia D Andl
Jul 29, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Anupam DasAnjan Chakraborty
Sep 3, 2016·BMC Systems Biology·Yu-Ching HsuEric Y Chuang
Aug 30, 2016·Journal of Natural Products·Valéria GrobárováJan Černý
Aug 18, 2016·Chemical Research in Toxicology·Elizabeth G GibsonJoseph E Deweese
Sep 22, 2016·Nature Reviews. Molecular Cell Biology·Yves PommierJohn L Nitiss
Sep 26, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Moumita Roy ChowdhuryGunjan Guha
Oct 1, 2016·Medicinal Research Reviews·Sandhya BansalVibha Tandon
Sep 21, 2016·ACS Chemical Biology·Imogen A RiddellStephen J Lippard
Oct 9, 2016·BMC Microbiology·Dorit Lubitz, Volker F Wendisch
Oct 19, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mirela EnacheMadalin I Enache
Oct 23, 2016·Apoptosis : an International Journal on Programmed Cell Death·V Lakshma NayakAhmed Kamal
Oct 27, 2016·ACS Applied Materials & Interfaces·Subhajit GhoshSurajit Ghosh
Nov 1, 2016·Science Translational Medicine·Yves PommierJohann de Bono
Nov 14, 2016·Cellular Signalling·Claudia SchäferOliver H Krämer
Dec 24, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Harish C Pal, Santosh K Katiyar
Jul 28, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles GuenanciaCatherine Vergely
Dec 23, 2016·Scientific Reports·Elisé P WrightZoë A E Waller
Feb 22, 2017·Journal of Pathology and Translational Medicine·Young Wha KohJooryung Huh
Jan 11, 2017·Journal of Medicinal Chemistry·Giovanni CapranicoGiovanni Chillemi
Apr 13, 2017·Expert Opinion on Drug Discovery·Robert Musiol
Apr 14, 2017·Journal of Medicinal Chemistry·Philippe PanchaudGeorg Rueedi
Jan 16, 2015·Anais Da Academia Brasileira De Ciências·Giovana N M EsquissatoMarialba A A De Castro-Prado
Apr 8, 2017·International Journal of Molecular Sciences·Xiaozeng LinDamu Tang
Jun 6, 2016·Bioorganic & Medicinal Chemistry Letters·Bradley R KossmannIvaylo Ivanov
Jun 2, 2017·Biological & Pharmaceutical Bulletin·Graciela Pinto VitorinoMaría Rosa Mazzieri
Feb 11, 2014·Bioorganic & Medicinal Chemistry Letters·Patrícia de Oliveira FigueiredoWalmir Silva Garcez
Apr 29, 2014·Biochemistry·Nicholas A SmithNeil Osheroff
Jan 4, 2017·Bioorganic & Medicinal Chemistry Letters·Idaira Hueso-FalcónAna Estévez-Braun
Dec 22, 2016·Bioorganic & Medicinal Chemistry Letters·Lorena Infante LaraNeil Osheroff
Jan 14, 2016·Metallomics : Integrated Biometal Science·Mariana S de CamargoAlzir A Batista
Jun 29, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mirela EnacheMadalin I Enache
Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Agnieszka GornowiczZbigniew Kałuża
Sep 8, 2017·International Journal of Molecular Sciences·Dorte Lisbet NielsenBirgitte Martine Viuff
Oct 14, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Monika ŚwierczewskaRadosław Januchowski
Feb 2, 2018·International Journal of Molecular Sciences·Hueng-Chuen FanHorng-Jyh Harn
Feb 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joel PardoRoger M Leblanc
Jan 6, 2018·International Journal of Molecular Sciences·Ricky S JoshiJoaquim Roca
May 3, 2018·Expert Opinion on Therapeutic Patents·O A Luzina, N F Salakhutdinov
Dec 5, 2017·Frontiers in Molecular Biosciences·Anthony J Berdis
Apr 21, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·S ImstepfR Alberto
Aug 12, 2017·Cell Death and Differentiation·Kerstin BrinkmannAndreas Strasser
Apr 24, 2018·The Plant Journal : for Cell and Molecular Biology·Vonny SalimDean DellaPenna
Oct 24, 2017·Metallomics : Integrated Biometal Science·Vineet KumarDipak Dutta
Oct 28, 2017·The Journal of Biological Chemistry·Joyce H LeeJames M Berger
Jan 20, 2012·Nature·Christopher J Lord, Alan Ashworth
Jul 18, 2018·Water Science and Technology : a Journal of the International Association on Water Pollution Research·B NunesS C Antunes
Aug 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katerina Cermakova, H Courtney Hodges
Sep 8, 2018·Journal of Enzyme Inhibition and Medicinal Chemistry·Anastasia O KomarovaOlga I Lavrik
Dec 24, 2014·Antimicrobial Agents and Chemotherapy·Adwait Anand GodboleValakunja Nagaraja
Aug 8, 2015·PloS One·Ming Zhao, Ruth A Gjerset
Jun 17, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jing Lu LiangYurngdong Jahng
Dec 15, 2015·The Journal of Biological Chemistry·Katherine M Evans-RobertsAnthony Maxwell
Dec 12, 2018·Molecular Nutrition & Food Research·Anika SchroeterDoris Marko
Feb 6, 2019·International Journal of Molecular Sciences·Sarah AlexandrouC Elizabeth Caldon
Mar 1, 2019·Organic & Biomolecular Chemistry·Wenjie LangJingyan Ge
Nov 2, 2018·Endocrine-related Cancer·Simon LinderStefan Prekovic
Mar 26, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Qian YuLin-Kun An
Dec 17, 2011·Nature Reviews. Drug Discovery·Yves Pommier, Christophe Marchand
Jun 12, 2019·Expert Review of Anticancer Therapy·Burak Yasin AktasOmer Dizdar
Jun 20, 2019·Archiv der Pharmazie·Mohamed A A Abdel-AalGamal El-Din A A Abuo-Rahma
Mar 9, 2019·Anti-cancer Agents in Medicinal Chemistry·Yu-Lian XuJin-Jian Lu
Oct 5, 2013·Clinical Pharmacology and Therapeutics·P Vejpongsa, E T H Yeh
Sep 15, 2017·The Journal of Pharmacology and Experimental Therapeutics·Steven R HallKerry B Goralski
Sep 10, 2014·Acta Crystallographica. Section F, Structural Biology Communications·Yin-Cheng HsiehChun-Jung Chen
Jun 4, 2014·Molecular Pharmacology·Salim KhiatiYves Pommier
Nov 23, 2018·Science China. Life Sciences·Yesheng YinXiaobo Qiu
Jul 26, 2017·Chemical & Pharmaceutical Bulletin·Rosa María Chávez-SantosRoberto Martínez
Nov 1, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Carolina G OliveiraVictor M Deflon
Oct 25, 2019·Biomolecules & Therapeutics·Minji BangChan Young Shin
Jul 6, 2014·Current Protocols in Cytometry·Hong Zhao, Zbigniew Darzynkiewicz
Jun 12, 2012·Current Protocols in Pharmacology·John L NitissMargarita Mishina
May 19, 2018·Current Medicinal Chemistry·Rosa M RegueraRafael Balaña-Fouce
Jan 9, 2020·Natural Product Reports·Yan YanYi Tang
Oct 18, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aleksander S FilimonovO I Lavrik
Feb 6, 2018·Advanced Pharmaceutical Bulletin·Roman AkasovElena Markvicheva
Apr 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Georg AichingerDoris Marko
Apr 22, 2020·ChemMedChem·Maristela B Martins-Teixeira, Ivone Carvalho
Oct 23, 2019·Acta Crystallographica. Section E, Crystallographic Communications·Sonia HayaniYoussef Kandri Rodi
Feb 12, 2017·Oncotarget·Vlad C SandulacheStephen Y Lai
Oct 6, 2017·Oncotarget·Xiaoyang LiZhenfeng Duan
Dec 14, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Egemen Fotoİsmail Yalçın
Nov 29, 2016·Oncotarget·Selma M CuyaRobert C A M van Waardenburg
Mar 13, 2016·ChemMedChem·Di Song, Shutao Ma
May 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paula C AlvesVânia André
May 18, 2020·Proceedings of the National Academy of Sciences of the United States of America·Christian F NielsenDamien F Hudson
Jun 20, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Valeria VisoneAnna Valenti
May 17, 2011·Journal of Immunoassay & Immunochemistry·Zahra AmirghofranMaryam Esmaeilbeig
Jul 2, 2020·Transactions of the Royal Society of Tropical Medicine and Hygiene·Robab AzargunShirin Eyvazi
Jul 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wei ZhouZhiyun Du
Oct 30, 2019·Mini Reviews in Medicinal Chemistry·Bhushan Shakya, Paras Nath Yadav
Jul 31, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi KadowakiIssei Komuro
Jul 28, 2020·Chemical Communications : Chem Comm·Dongdong XuSeraphine V Wegner
Mar 12, 2015·The Journal of Pharmacology and Experimental Therapeutics·Yuqiao ShenBing Wang
Mar 5, 2016·Chemical & Pharmaceutical Bulletin·Donggen PiaoJong-Keun Son
Dec 12, 2012·Genes & Genetic Systems·Akiko SakaiYoshihiko Maehara
Feb 20, 2015·Nature Reviews. Cancer·Mohamed E AshourSherif F El-Khamisy
Mar 22, 2015·The Journal of Biological Chemistry·Christine M WrightMary-Ann Bjornsti
Jun 10, 2015·The Journal of Biological Chemistry·Devaraja G MudeppaPradipsinh K Rathod
Nov 18, 2015·Molecular Medicine Reports·Chengshan XuChengrong Lu
Feb 14, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Vinodkumar B PillaiMahesh P Gupta
May 24, 2017·Proceedings of the National Academy of Sciences of the United States of America·Hui YangZhijian J Chen
Aug 19, 2017·Scientific Reports·Hongliang ZhangYves Pommier
Sep 29, 2017·Chemical & Pharmaceutical Bulletin·Tae In KimJong Keun Son
Nov 29, 2017·Journal of Nucleic Acids·Farhaan A Khan, Syed O Ali
Feb 16, 2018·Current Medicinal Chemistry·Hamada H H MohammedEl-Shimaa M N Abdelhafez
Jun 16, 2018·F1000Research·Ashwani KesarwaniPramod Upadhyay
Aug 8, 2018·Nature Communications·Shin-Fu ChenNei-Li Chan
Sep 28, 2018·International Journal of Molecular Sciences·Karolina SterzyńskaRadosław Januchowski
Jan 10, 2019·Nature Communications·S A BaechlerYves Pommier
Jan 19, 2019·Anti-cancer Agents in Medicinal Chemistry·Harbinder SinghSahil Sharma
Jan 9, 2019·Frontiers in Pharmacology·Yiming ChenLei Zhang
Sep 19, 2019·Marine Drugs·Jortan O TunGisela P Concepcion
Sep 14, 2019·Molecular Pharmacology·Ian G CowellCaroline A Austin
Sep 6, 2019·International Journal of Molecular Sciences·Janina EnderleHolger Puchta
Oct 2, 2020·International Journal of Molecular Sciences·Elizaveta D GladkovaO I Lavrik
Mar 22, 2014·Natural Product Reports·Antonio EvidenteRobert Kiss
Nov 8, 2014·Organic & Biomolecular Chemistry·Junyan HanDaniel Y Lee
May 7, 2014·The Journal of Biological Chemistry·Ilaria Dalla RosaYves Pommier
Dec 30, 2014·Médecine sciences : M/S·Julie PapillonValérie Lamour
Dec 3, 2014·The Journal of Biological Chemistry·Lin-Yu LuXiaochun Yu
Apr 19, 2015·The Journal of Biological Chemistry·Shar-yin N HuangYves Pommier
Jun 24, 2016·G3 : Genes - Genomes - Genetics·Morgan A SammonsShelley L Berger
Jul 1, 2017·Histochemistry and Cell Biology·Aleksandra Divac RankovJelena Dinić
Feb 6, 2018·Annual Review of Cancer Biology·Devon M FitzgeraldSusan M Rosenberg
Sep 22, 2017·Frontiers in Immunology·Mohammad H SalehArmand Keating
Nov 11, 2017·FEMS Microbiology Reviews·Mark J ButtnerAnthony Maxwell
Sep 14, 2018·Scientific Reports·Hilal Taymaz-NikerelBetül Kırdar
Jan 25, 2019·Journal of Experimental & Clinical Cancer Research : CR·Jui-Chih ChangChin-San Liu
Nov 12, 2019·Journal of Cellular Physiology·Sama IzadpanahBehzad Baradaran
Jul 28, 2020·Journal of Toxicology·Olufunke Esan OlorundareHasan Mukhtar