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DNA-triplex stabilizing properties of 8-aminoguanine

Nucleic Acids Research

Nov 10, 2000

R SolivaM Orozco

Abstract

A DNA-triplex stabilizing purine (8-aminoguanine) is designed based on molecular modeling and synthesized. The substitution of guanine by 8-aminoguanine largely stabilizes the triplex both at neutral and acidic pH, as suggested by molecular dynamics and thermodynamic integration calcula...read more

Mentioned in this Paper

Guanine
Thermodynamics
Molecular Dynamics
In Vivo NMR Spectroscopy
RNA Conformation
RNA Denaturation
Structure-Activity Relationship
Molecular Modeling
Cytosine
triplex DNA
20
Paper Details
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  • Citations21
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  • References31
  • Citations21
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DNA-triplex stabilizing properties of 8-aminoguanine

Nucleic Acids Research

Nov 10, 2000

R SolivaM Orozco

PMID: 11071942

DOI: 10.1093/nar/28.22.4531

Abstract

A DNA-triplex stabilizing purine (8-aminoguanine) is designed based on molecular modeling and synthesized. The substitution of guanine by 8-aminoguanine largely stabilizes the triplex both at neutral and acidic pH, as suggested by molecular dynamics and thermodynamic integration calcula...read more

Mentioned in this Paper

Guanine
Thermodynamics
Molecular Dynamics
In Vivo NMR Spectroscopy
RNA Conformation
RNA Denaturation
Structure-Activity Relationship
Molecular Modeling
Cytosine
triplex DNA
20

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Mutations, single nucleotide variants and large genomic rearrangements in non-coding regions of the genome can have severe consequences such as disruption of transcription factor binding sites and functions of non-coding RNAs and can impact tumor development and progression. This feed focuses on the latest research on non-coding variants in cancer.

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Paper Details
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