PMID: 8589046Oct 1, 1995Paper

DNA typing of DQ and DR alleles in IgA-deficient subjects

European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics
M FioreClaudio Pignata

Abstract

IgA deficiency (IgA-D) represents the most common immunodeficiency syndrome of infancy. In most cases IgA-D represents an isolated immunological disorder, while sometimes it is associated with IgG subclass deficiency or with the presence of autoantibodies. We investigated the pattern of association of IgA-D with DRB1 and DQB1 loci of the HLA region by DNA molecular typing, which allows the identification of previously serologically undefined specificities. We also compared the gene frequency of DRB1 and DQB1 allelic variants between IgA-D subjects with or without serum autoantibodies. Our results indicate that the gene frequency of the DRB1*0102 subtype and of the DRB1*0102, DQB1*0501 haplotype is significantly higher in IgA-D than in the general population. Furthermore, the IgA-D subjects with autoantibodies showed a positive association with DR4 and DR13 subtypes, thus supporting the hypothesis that genetic factors are also involved in the association between IgA-D and autoantibodies.

References

Dec 1, 1979·Clinical Immunology and Immunopathology·A J AmmannN Talal
Jul 1, 1979·The Journal of Clinical Investigation·C Cunningham-RundlesN K Day
Jan 1, 1975·Vox Sanguinis·J Koistinen
Jan 1, 1975·Vox Sanguinis·J Koistinen, S Sarna
May 1, 1977·Clinical Immunology and Immunopathology·M AmbrusG Bajtai
Sep 11, 1976·The Journal of Pediatrics·M E GershwinW Strober
Jun 26, 1975·Nature·C R StokesM W Turner
Dec 1, 1992·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·C PeraG B Ferrara
Jan 1, 1992·International Archives of Allergy and Immunology·R S Liblau, J F Bach
Jul 1, 1991·Human Immunology·S G Marsh, J G Bodmer
Nov 1, 1991·Clinical Immunology and Immunopathology·C Cunningham-RundlesJ B Peter
Apr 1, 1991·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A JiménezG Fontán
Aug 1, 1990·Immunology Today·M A French, R L Dawkins
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·F M SchafferJ E Volanakis
Aug 1, 1989·Tissue Antigens·M Cuccia-BelvedereG R Burgio
Oct 1, 1988·Tissue Antigens·T KlemolaP Pelkonen
Jun 1, 1988·Archives of Disease in Childhood·G Morgan, R J Levinsky
Jul 1, 1986·Human Immunology·R StrothmanM J Ball
Jan 1, 1985·The Tohoku Journal of Experimental Medicine·N FunakoshiH Uchino
Jan 1, 1983·Tissue Antigens·L Hammarström, C I Smith
Jun 11, 1981·The New England Journal of Medicine·V A OxeliusL A Hanson
Jul 5, 2007·Journal of Lipid Research·Barbara P AtshavesFriedhelm Schroeder

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Citations

May 3, 2012·Seminars in Immunopathology·Kimberly P Newton, Shereen A Singer
Mar 18, 2003·Diabetes Research and Clinical Practice·Midori FujishiroTomoichiro Asano
Jun 14, 2000·Tissue Antigens·E G De la ConchaG Fontan
Aug 10, 2000·Scandinavian Journal of Immunology·H K MacHullaJ Langner
Jan 19, 2012·International Reviews of Immunology·Giuseppina AlojClaudio Pignata
Oct 28, 2015·Nutrients·Rachele CiccocioppoLuis Rodrigo
May 23, 2003·Genes and Immunity·A MartínezE G de la Concha Ed
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emilio G De la ConchaGumersindo Fontan
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·I VorechovskýA D Webster
Sep 13, 2001·Mental Retardation and Developmental Disabilities Research Reviews·M Hornig, W I Lipkin

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