DNA Uptake by Type IV Filaments

Frontiers in Molecular Biosciences
Kurt H Piepenbrink

Abstract

Bacterial uptake of DNA through type IV filaments is an essential component of natural competence in numerous gram-positive and gram-negative species. Recent advances in the field have broadened our understanding of the structures used to take up extracellular DNA. Here, we review seminal experiments in the literature describing DNA binding by type IV pili, competence pili and the flp pili of Micrococcus luteus; collectively referred to here as type IV filaments. We compare the current state of the field on mechanisms of DNA uptake for these three appendage systems and describe the current mechanistic understanding of both DNA-binding and DNA-uptake by these versatile molecular machines.

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Citations

Dec 1, 2019·Medical Microbiology and Immunology·Theis JacobsenMichael Nilges
Aug 9, 2020·Frontiers in Molecular Biosciences·Divya Singhi, Preeti Srivastava
Jul 11, 2020·Nature Communications·Fengbin WangEdward H Egelman
Aug 21, 2020·Journal of Bacteriology·Dallas R FonsecaKyle C Costa
Dec 8, 2020·Molecular Microbiology·Souvik NaskarHarry H Low
Sep 23, 2021·Nature Reviews. Microbiology·Navish Wadhwa, Howard C Berg
Nov 18, 2021·FEMS Microbiology Reviews·Courtney K EllisonYves V Brun
Dec 18, 2021·Analytical Methods : Advancing Methods and Applications·Tamás VermesAndreas Urban

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Methods Mentioned

BETA
transmission electron microscopy
glycosylation
NMR

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