DNA vaccine against malaria: a long way to go

Critical Reviews in Biochemistry and Molecular Biology
Renu Tuteja

Abstract

Vaccination is the attempt to mimic certain aspects of an infection for the purpose of causing an immune response that will protect the individual from that infection. Malaria, a disease responsible for immense human suffering, is caused by infection with Plasmodium spp. parasites, which have a very complex life cycle--antigenically unique stages infect different tissues of the body. It is a parasitic disease for which no successful vaccine has been developed so far, despite considerable efforts to develop a subunit vaccine that offers protective immunity. Due to the spread of drug-resistant malaria, efforts to develop an effective vaccine have become increasingly critical. DNA vaccination provides a stable and long-lived source of protein vaccine capable of inducing both antibody- and cell-mediated immune responses to a wide variety of antigens. Injected DNA enters the cells of the host and makes the protein, which triggers the immune response. According to present needs, the flexibility of DNA vaccine technology permits the combination of multiple antigens from both the preerythrocytic and erythrocytic stages of malaria parasite. DNA vaccines with genes coding for different antigenic parts of malaria proteins have been create...Continue Reading

Citations

Jan 13, 2009·Journal of Industrial Microbiology & Biotechnology·Adam SingerElliot Altman
Feb 14, 2013·Human Vaccines & Immunotherapeutics·Ramesh VermaSuraj Chawla
Aug 31, 2006·Applied Microbiology and Biotechnology·Kristala L Jones PratherJerrell W Herod
Dec 3, 2020·Canadian Journal of Microbiology·Raquel L RussellBrian L Mark
May 26, 2004·Archives of Biochemistry and Biophysics·A Kwame NyameRichard D Cummings

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