DNA vaccines for biodefense

Expert Review of Vaccines
Lesley C Dupuy, Connie S Schmaljohn

Abstract

An ideal biodefense vaccine platform would allow for the quick formulation of novel vaccines in response to emerging or engineered pathogens. The resultant vaccine should elicit protective immune responses in one to three doses and be unaffected by pre-existing immunity to vaccine components. In addition, it should be amenable to combination and multi-agent formulation, and should be safe for all populations and the environment. DNA vaccines can potentially meet all of these requirements; thus, this platform is being tested with several biodefense threats. Here, we provide a review of the current status of the development efforts for DNA vaccines against several relevant biodefense pathogens: Bacillus anthracis, Ebola and Marburg viruses, smallpox virus, and Venezuelan equine encephalitis virus.

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Citations

Jan 16, 2014·International Journal of Nanomedicine·Kai ZhaoYunfeng Wang
Dec 10, 2014·Expert Review of Vaccines·Kate E Broderick, Laurent M Humeau
Oct 2, 2014·Expert Review of Vaccines·Karl Ljungberg, Peter Liljeström
Aug 3, 2011·Expert Review of Vaccines·Joseph W Golden, Jay W Hooper
Apr 8, 2016·Expert Review of Vaccines·Peter PushkoIrina Tretyakova
May 17, 2019·Science Translational Medicine·Sung-Youl KoSrinivas S Rao
Oct 19, 2017·Human Vaccines & Immunotherapeutics·Kathleen A CashmanConnie S Schmaljohn
Aug 2, 2021·Molecular Aspects of Medicine·Manish PandeyGeetanjali Chawla

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