DNA Virus Vectors for Vaccine Production in Plants: Spotlight on Geminiviruses

Vaccines
Kathleen Hefferon

Abstract

Plants represent a safe, efficacious and inexpensive production platform by which to provide vaccines and other therapeutic proteins to the world's poor. Plant virus expression vector technology has rapidly become one of the most popular methods to express pharmaceutical proteins in plants. This review discusses several of the state-of-the-art plant expression systems based upon geminiviruses that have been engineered for vaccine production. An overview of the advantages of these small, single-stranded DNA viruses is provided and comparisons are made with other virus expression systems. Advances in the design of several different geminivirus vectors are presented in this review, and examples of vaccines and other biologics generated from each are described.

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Citations

Dec 2, 2014·Current Opinion in Biotechnology·Cara L MortimerJames L Dale
Jul 20, 2017·Current Medicinal Chemistry·Lilya Kopertekh, Joachim Schiemann
Nov 24, 2019·Molecular Biotechnology·Vrinda M Kurup, Jaya Thomas
Aug 2, 2017·Biomedicines·Kathleen Hefferon
Jan 7, 2020·Critical Reviews in Biotechnology·Nikolay E ZlobinVasiliy V Taranov
Nov 27, 2019·Plant Biotechnology·Takuya SuzakiKenji Miura
Jan 6, 2021·Vaccines·Nasir MahmoodKathleen Hefferon
Dec 31, 2020·Viruses·Zacharie LeBlancJulia Bally
Aug 7, 2021·Vaccines·Srividhya VenkataramanMounir Abouhaidar

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Methods Mentioned

BETA
transgenic
ELISA
flow cytometry

Software Mentioned

BeYDV

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