PMID: 9643311Jun 27, 1998Paper

DNAse treatment does not improve the survival of lupus prone (NZB x NZW)F1 mice

Lupus
D VerthelyiD M Klinman

Abstract

To examine the efficacy of deoxyribonuclease I (DNAse) therapy in the (NZB x NZW)F1 murine model of lupus. Lupus-prone female (NZB x NZW)F1 mice were treated daily with 0-15 microg/g of recombinant DNAse for 1-6 months. Parameters including anti-DNA autoantibody production, activation of cytokine secreting cells, kidney function and longevity were monitored. DNAse treatment selectively reduced the number of B cells secreting anti-dsDNA antibodies for approximately one month. However, neither short-term nor long-term treatment altered cytokine production, delayed the onset or reduced the severity of glomerulonephritis, or prolonged survival. DNAse treatment initiated before, during, or after the onset of murine lupus did not improve clinical outcome.

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Citations

Oct 20, 2011·Nature Reviews. Rheumatology·Steffen Frese, Betty Diamond
Jun 1, 2013·The Journal of Clinical Investigation·Jason S KnightMariana J Kaplan
Jun 12, 2013·Molecular Medicine·Natalya SeredkinaOle Petter Rekvig
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Nov 18, 2015·Seminars in Nephrology·Hege Lynum PedersenOle Petter Rekvig
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Jul 16, 2020·Biomolecules·Lucia LaukováPeter Celec
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Jan 19, 2018·Expert Reviews in Molecular Medicine·Peter CelecPeter Boor
Apr 9, 2021·Frontiers in Medicine·Maurizio BruschiGian Marco Ghiggeri

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