DNaseI in pathogenesis of systemic lupus erythematosus

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Shin-Ichi Tsukumo, Koji Yasutomo

Abstract

The aberrant activation of lymphocytes causes autoimmune diseases. Although there are many candidate molecules that are involved in the pathogenesis of autoimmune diseases, it still remains unclear how immunological tolerance is disturbed in each autoimmune disease. Recently, we discovered two patients suffering from systemic lupus erythematosus (SLE) with a defect in the DNaseI gene locus. According to immunological and genetic analysis, we hypothesize that defective antigen clearance, especially accumulation of nucleosomal antigens, is responsible for the development of SLE. In this article, we review the pathogenesis of SLE from the view of defective self-antigen clearance due to low DNaseI activity.

References

Apr 1, 1977·Annals of the Rheumatic Diseases·P DavisA S Russell
Aug 1, 1988·Journal of Autoimmunity·F M BrennanM Feldmann
May 1, 1986·Annals of the Rheumatic Diseases·A J SwaakW Bronsveld
Jan 1, 1981·Rheumatology International·S ChitrabamrungE M Tan
Mar 1, 1996·The Journal of Clinical Investigation·J E SalmonR P Kimberly
Nov 1, 1996·Science·T L O'KeefeM S Neuberger
May 23, 1998·Annual Review of Immunology·T J Vyse, B L Kotzin
Jun 3, 1999·Critical Reviews in Immunology·M Z RadicS N Seal
Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·M BoesJ Chen
Mar 21, 2000·Rheumatology·M C Pickering, M J Walport
Jun 3, 2000·Nature Genetics·M NapireiT Möröy
Oct 6, 2000·Science·S Fagarasan, T Honjo
May 11, 2001·Nature·R S ScottG K Matsushima
Aug 2, 2001·Nature Genetics·K YasutomoY Kuroda
Aug 2, 2001·Nature Medicine·P MarrackB L Kotzin
Sep 25, 2001·Immunity·E K WakelandT W Behrens
Apr 12, 2002·Nature·Elizabeth A LeadbetterAnn Marshak-Rothstein
Jul 30, 2002·American Journal of Human Genetics·Robert R GrahamTimothy W Behrens
Nov 5, 2003·Trends in Immunology·Betty P Tsao
Mar 17, 2004·Arthritis and Rheumatism·Lesley J MasonDavid A Isenberg

❮ Previous
Next ❯

Citations

Nov 30, 2006·Immunology and Cell Biology·A Tarkowski
May 6, 2011·Arthritis Research & Therapy·Annica HedbergOle Petter Rekvig
Nov 1, 2008·The International Journal of Biochemistry & Cell Biology·Sebastian LudwigMarkus Napirei
Aug 12, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Rachel E RigbyAndrew P Jackson
Oct 13, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Irene C B ViorrittoRichard M Siegel
Nov 18, 2015·Seminars in Nephrology·Hege Lynum PedersenOle Petter Rekvig
Dec 15, 2005·The International Journal of Biochemistry & Cell Biology·Markus NapireiHans Georg Mannherz
Aug 5, 2008·Analytical Biochemistry·Shinobu SatoShigeori Takenaka
May 5, 2007·Nature Medicine·Roberto BaccalaArgyrios N Theofilopoulos
Dec 12, 2012·Virchows Archiv : an International Journal of Pathology·Helmut H Popper
Sep 28, 2013·Journal of Applied Physiology·Nicolas ValléeJean-Eric Blatteau
Mar 7, 2017·Autoimmunity·Nikolaos K GatselisGeorge N Dalekos
Jul 16, 2020·Immunity·Sarah M McWhirter, Caroline A Jefferies
Aug 26, 2014·Disease Models & Mechanisms·Steve P CramptonSilvia Bolland

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

The International Journal of Biochemistry & Cell Biology
Markus NapireiHans Georg Mannherz
Autoimmunity Reviews
Fernando Martínez ValleMiquel Vilardell-Tarres
© 2021 Meta ULC. All rights reserved