Apr 24, 2020

Fussing about fission: defining variety among mainstream and exotic apicomplexan cell division modes

BioRxiv : the Preprint Server for Biology
Marc-Jan GubbelsM. T. Duraisingh

Abstract

Cellular reproduction defines life, yet our textbook-level understanding of cell division is limited to a small number of model organisms centered around humans. The horizon on cell division variants is expanded here by advancing insights on the fascinating cell division modes found in the Apicomplexa, a key group of protozoan parasites. The Apicomplexa display remarkable variation in offspring number, whether karyokinesis follows each S/M-phase or not, and whether daughter cells bud in the cytoplasm or bud from the cortex. We find that the terminology used to describe the various manifestations of asexual apicomplexan cell division emphasizes either the number of offspring or site of budding, which are not directly comparable features and has led to confusion in the literature. Division modes have been primarily studied in two human pathogenic Apicomplexa, malaria-causing Plasmodium spp. and Toxoplasma gondii, a major cause of opportunistic infections. Plasmodium spp. divide asexually by schizogony, producing multiple daughters per division round through a cortical budding process, though at several life-cycle nuclear amplifications are not followed by karyokinesis. T. gondii divides by endodyogeny producing two internally bud...Continue Reading

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Mentioned in this Paper

Vertebrates
Apis mellifera
In Vivo
Biological Neural Networks
Periodontal Attachment Loss
Structure of Olfactory Bulb
Cytosine
Memory, Long-Term
Smell Perception
Neuronal Plasticity

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