DNN-assisted statistical analysis of a model of local cortical circuits.

Scientific Reports
Yaoyu Zhang, Lai-Sang Young

Abstract

In neuroscience, computational modeling is an effective way to gain insight into cortical mechanisms, yet the construction and analysis of large-scale network models-not to mention the extraction of underlying principles-are themselves challenging tasks, due to the absence of suitable analytical tools and the prohibitive costs of systematic numerical exploration of high-dimensional parameter spaces. In this paper, we propose a data-driven approach assisted by deep neural networks (DNN). The idea is to first discover certain input-output relations, and then to leverage this information and the superior computation speeds of the well-trained DNN to guide parameter searches and to deduce theoretical understanding. To illustrate this novel approach, we used as a test case a medium-size network of integrate-and-fire neurons intended to model local cortical circuits. With the help of an accurate yet extremely efficient DNN surrogate, we revealed the statistics of model responses, providing a detailed picture of model behavior. The information obtained is both general and of a fundamental nature, with direct application to neuroscience. Our results suggest that the methodology proposed can be scaled up to larger and more complex biolo...Continue Reading

References

Jul 1, 1982·Journal of Neurophysiology·D G Albrecht, D B Hamilton
Dec 6, 1996·Science·C van Vreeswijk, H Sompolinsky
Aug 11, 1998·Neural Computation·C van Vreeswijk, H Sompolinsky
Jun 28, 2000·Proceedings of the National Academy of Sciences of the United States of America·D McLaughlinD J Wielaard
May 16, 2001·Journal of Neurophysiology·M P SceniakR Shapley
Feb 11, 2005·Journal of Neurophysiology·J Andrew Henrie, Robert Shapley
Jul 19, 2005·Annual Review of Neuroscience·Tim P VogelsL F Abbott
Sep 28, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jessica A CardinDiego Contreras
Jun 18, 2010·Current Psychiatry Reports·Guillermo Gonzalez-BurgosDavid A Lewis
Mar 27, 2012·Current Opinion in Neurobiology·Michelle M McCarthyNancy Kopell
Oct 19, 2014·Journal of Computational Neuroscience·Logan Chariker, Lai-Sang Young
May 29, 2015·Nature·Yann LeCunGeoffrey Hinton
Aug 1, 2015·PLoS Computational Biology·Omri Harish, David Hansel
Oct 10, 2015·Cell·Henry MarkramFelix Schürmann
Jan 8, 2016·Journal of Neurophysiology·Ashok Litwin-KumarBrent Doiron
Feb 26, 2016·Nature Neuroscience·Daniel L K Yamins, James J DiCarlo
Jun 4, 2016·PloS One·W Andrew Pruett, Robert L Hester
Dec 9, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Logan CharikerLai-Sang Young
Feb 2, 2017·PLoS Computational Biology·Jannis SchueckerMoritz Helias
Jul 12, 2017·Neuron·Hiroyuki K KatoJeffry S Isaacson
Sep 8, 2017·Frontiers in Computational Neuroscience·Jyotika BahugunaAbigail Morrison
Oct 28, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sadra SadehDylan Richard Muir
Mar 6, 2018·Neuron·Alexandra K MooreMichael Wehr
Aug 19, 2018·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Logan CharikerLai-Sang Young
Oct 20, 2018·PLoS Computational Biology·Maximilian SchmidtSacha Jennifer van Albada
Apr 25, 2020·Journal of Vision·Logan CharikerLai-Sang Young

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques

Software Mentioned

Pytorch
qquad
Tensorflow
Keras

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved