DNQX in the nucleus accumbens inhibits cocaine-induced conditioned place preference

Brain Research
F G KaddisL J Wallace

Abstract

Several lines of evidence suggest that activation of both AMPA/kainate receptors and dopaminergic receptors in the nucleus accumbens may be required for psychostimulant drug induced reward. However, it has been reported that dopaminergic antagonists fail to block acquisition of conditioned place preference to cocaine. The goal of these experiments was to determine whether AMPA receptor antagonist injected into the nucleus accumbens could block conditioned place preference elicited by cocaine under conditions where dopaminergic antagonists do not inhibit acquisition of place preference. DNQX (1 microgram/0.5 microliter), injected into the nucleus accumbens just before systemic injections of cocaine (20 mg/kg i.p.) during the training sessions, attenuated the acquisition of place preference. This suggests that AMPA receptors are involved in acquisition of place preference to cocaine. By contrast, fluphenazine (2.5 micrograms/0.5 microliter), injected into the nucleus accumbens during training, did not alter cocaine-induced place preference. Analysis of locomotor activity showed that the ability of flyphenazine to inhibit cocaine-induced hyperactivity progressively decreased with each training session. These observations suggest t...Continue Reading

Citations

Mar 2, 2006·The Journal of Pharmacology and Experimental Therapeutics·Laurie H L SellingsPaul B S Clarke
Oct 9, 2012·Science·Ja Wook KooEric J Nestler
Dec 13, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jennifer M BossertYavin Shaham
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