Do A-waves help predict intravenous immunoglobulin response in multifocal motor neuropathy without block?

Muscle & Nerve
Dale J LangeAnnabel K Wang

Abstract

Are there electrophysiological findings that predict response to intravenous immunoglobulin (IVIg) in patients with lower motor neuron (LMN) syndromes without multifocal conduction block (MCB)? We enrolled 9 patients with LMN syndromes without MCB to receive 18 weeks of IVIg therapy. Response was measured at weeks 2 and 18 using the Appel Amyotrophic Lateral Sclerosis (AALS) score (includes grip and pincer strength measures), ALS Functional Rating Scale (ALSFRS), and electrophysiological measures, including motor unit estimates (MUNEs). No change occurred in AALS or ALSFRS scores posttreatment. Grip/pincer strength increased in 7 patients (P = 0.028) after initial treatment (responders); 2 showed no improvement (non-responders). No electrophysiological measure changed after treatment in either group but MUNEs trended higher (P = 0.055). "Abnormal A-waves" (complex, repetitive biphasic, or present in multiple nerves) occurred in pretreatment studies more often in responders (P = 0.028). "Abnormal A-waves" may signal IVIg-responsive LMN syndromes even if conduction block is absent.

References

Apr 1, 1992·Electroencephalography and Clinical Neurophysiology·M R Magistris, G Roth
Oct 1, 1992·Muscle & Nerve·D R CornblathD B Drachman
Nov 11, 1992·Neurology·J J Kelly
Sep 1, 1993·Seminars in Neurology·G J Parry
Sep 1, 1993·Muscle & Nerve·D J LangeD M Blake
Jan 7, 1998·Journal of the Neurological Sciences·J M Cedarbaum, N Stambler
Feb 18, 1998·Muscle & Nerve·A S Pakiam, G J Parry
Jun 17, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·C M EllisP N Leigh
Jan 14, 2000·Archives of Neurology·B J TraynorO Hardiman
Feb 19, 2000·Muscle & Nerve·M de Carvalho, M Swash
Jul 7, 2000·Muscle & Nerve·J Rowin, M N Meriggioli
Mar 2, 2002·Brain : a Journal of Neurology·Matthew C KiernanHugh Bostock
May 8, 2002·Muscle & Nerve·Kevin J Felice, Jonathan M Goldstein
Dec 13, 2002·Brain : a Journal of Neurology·J T H Van AsseldonkH Franssen
Feb 1, 1965·Journal of Neurology, Neurosurgery, and Psychiatry·P M FULLERTON, R W GILLIATT
Oct 23, 2003·Muscle & Nerve·Leena PuksaBjörn Falck
Dec 4, 2003·Journal of Neurology·R M Van Den Berg-VosJ H J Wokke
Mar 17, 2005·Muscle & Nerve·Eduardo Nobile-OrazioAlberto Priori
Apr 23, 2005·The Cochrane Database of Systematic Reviews·I N van SchaikM Vermeulen
Jun 28, 2006·Annals of Neurology·Merit E CudkowiczDaniel B Drachman
Aug 23, 2006·Neurology·Vinay Chaudhry, Michael Swash
Jul 27, 2007·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Peter Munch AndersenUNKNOWN EALSC Working Group
Sep 22, 2007·Current Opinion in Neurology·Richard Alan Lewis

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Citations

May 31, 2018·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Sindhuja LakshminarasimhanLakshminarasimhan Ranganathan

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