Do affective or dissociative symptoms mediate the association between childhood sexual trauma and transition to psychosis in an ultra-high risk cohort?

Psychiatry Research
Andrew ThompsonAshleigh Lin

Abstract

We have previously reported an association between childhood sexual trauma and transition to psychosis in an Ultra High Risk (UHR) population. We aimed to investigate if this association was mediated by affective or dissociative symptoms. Data were from a large UHR for psychosis cohort study. None of the potential mediators (depression, anxiety, dissociation, mood swings and mania, assessed by the HAM-D, HAM-A and the CAARMS symptom scales) significantly mediated the total association between sexual abuse scores and transition. At the point of transition, the mechanistic pathway from sexual trauma to psychosis does not appear to operate through affective symptoms.

References

Mar 10, 2001·Psychological Medicine·P A GaretyP E Bebbington
Dec 31, 2002·Schizophrenia Research·Alison R YungPatrick D McGorry
Mar 5, 2003·Child Abuse & Neglect·David P BernsteinWilliam Zule
Feb 27, 2004·Schizophrenia Research·Alison R YungPatrick D McGorry
May 18, 2004·European Archives of Psychiatry and Clinical Neuroscience·Heinz HäfnerWolfgang Wölwer
Dec 14, 2005·The Australian and New Zealand Journal of Psychiatry·Alison R YungJoe Buckby
Jan 16, 2007·Clinical Psychology Review·Inez Myin-Germeys, Jim van Os
Aug 16, 2008·Schizophrenia Bulletin·Richard P Bentall, Charles Fernyhough
Aug 25, 2009·Psychiatry Research·Daniel Freeman, David Fowler
Mar 5, 2010·Acta Psychiatrica Scandinavica·A BechdolfA R Yung
Oct 29, 2013·Schizophrenia Bulletin·Steven MarwahaDaniel Freeman
Oct 14, 2014·Social Psychiatry and Psychiatric Epidemiology·S Marwaha, P Bebbington
Dec 3, 2014·Comprehensive Psychiatry·Elisabeth HaugIngrid Melle

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Citations

Jul 17, 2016·Schizophrenia Bulletin·Rachel UpthegroveMax Birchwood
Jun 14, 2017·Translational Psychiatry·J DapuntA Heinz
Jan 22, 2018·European Psychiatry : the Journal of the Association of European Psychiatrists·Ilya BaryshnikovErkki Isometsä
Jul 29, 2020·Frontiers in Psychiatry·Kevin W HoffmanDolores Malaspina
Dec 15, 2020·Psychological Medicine·Daniela StrelchukStanley Zammit
Nov 12, 2019·Child and Adolescent Psychiatric Clinics of North America·Kate J StantonYael Dvir

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