Do all antioxidant supplements have the same potential effect on preventing myringosclerosis?

Clinical and Experimental Otorhinolaryngology
Seden AkdagliRefik Caylan

Abstract

Myringosclerosis is an irreversible pathological healing mechanism of the tympanic membrane which can result in the formation of sclerotic plaques. Antioxidant treatment is a recognised prevention therapy and coenzyme Q10 (CoQ10), lycopene, and grape seed extract (GSE), were used in this manner. Forty-four Wistar rats were used in this experiment, and, following myringotomies, the animals were randomly divided into four groups. CoQ10, lycopene or GSE was administered orally to the respective groups, starting from the day of surgery. Otomicroscopy examination was performed on the 14th day. All tympanic membrane lesions were evaluated and compared otomicroscopically and histopathologically. The otomicroscopy and histopathological findings, compared against a control (saline) group, showed the CoQ10, lycopene, and GSE groups had statistically significant differences of degree of sclerosis (P<0.001). CoQ10, lycopene, and GSE were compared against a saline group and their antioxidative and anti-inflammatory effects were similar. The formation of myringosclerotic plagues after experimental myringotomy in rats significantly decreased and diminished after systemic administration of the three different antioxidant supplements.

References

Jun 1, 1992·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·R E Beyer
Aug 1, 1995·The Annals of Otology, Rhinology, and Laryngology·C MattssonS Hellström
Sep 1, 1993·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·M H BhayaM M Paparella
Jun 1, 1997·The Annals of Otology, Rhinology, and Laryngology·C MattssonS Hellström
Jun 16, 2001·The Annals of Otology, Rhinology, and Laryngology·J E SpratleyM Pais-Clemente
May 9, 2002·International Journal of Pediatric Otorhinolaryngology·Cengiz OzcanIsmail Cinel
Oct 19, 2002·The Journal of Laryngology and Otology·Kemal GörürIsmail Cinel
Dec 22, 2005·International Journal of Pediatric Otorhinolaryngology·Cüneyd UneriMine Yazici
Jun 22, 2006·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·K Cagdas KazikdasZekiye Altun
May 8, 2007·Mitochondrion·Magnus BentingerGustav Dallner
Feb 10, 2009·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Hatice EmirHuseyin Ustun
Feb 11, 2009·The British Journal of Nutrition·Letícia BignottoHelder Mota-Filipe
Feb 5, 2011·Current Medicinal Chemistry·A MordenteV Böhm
Mar 1, 2012·International Journal of Pediatric Otorhinolaryngology·Jae-Jun SongSung-Won Chae

❮ Previous
Next ❯

Citations

Dec 30, 2015·Memory·Jakke TamminenVictoria J Williamson
Apr 4, 2020·Journal of Korean Medical Science·Eung Hyub KimYong Ho Park

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Vefa KinisIsmail Topcu
International Journal of Pediatric Otorhinolaryngology
Evin Das SahinAbdulvahap Akyigit
European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Necmi ArslanHaldun Oguz
© 2022 Meta ULC. All rights reserved