Do all men with pathological Gleason score 8-10 prostate cancer have poor outcomes? Results from the SEARCH database

BJU International
Sean FischerAdriana C Vidal

Abstract

To determine whether there are subsets of men with pathological high grade prostate cancer (Gleason score 8-10) with particularly high or low 2-year biochemical recurrence (BCR) risk after radical prostatectomy (RP) when stratified into groups based on combinations of pathological features, such as surgical margin status, extracapsular extension (ECE) and seminal vesicle invasion (SVI). We identified 459 men treated with RP with pathological Gleason score 8-10 prostate cancer in the SEARCH database. The men were stratified into five groups based on pathological characteristics: group 1, men with negative surgical margins (NSMs) and no ECE; group 2, men with positive surgical margin (PSMs) and no ECE; group 3, men with NSMs and ECE; group 4, men with PSMs and ECE; and group 5, men with SVI. Cox proportional hazards models and the log-rank test were used to compare BCR among the groups. At 2 years after RP, pathological group was significantly correlated with BCR (log-rank, P < 0.001) with patients in group 5 (+SVI) having the highest BCR risk (66%) and those in group 1 (NSMs and no ECE) having the lowest risk (14%). When we compared groups 2, 3, and 4, with each other, there was no significant difference in BCR among the groups ...Continue Reading

References

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Citations

Sep 14, 2016·Prostate Cancer and Prostatic Diseases·R ManoO Yossepowitch
May 21, 2019·The American Journal of Surgical Pathology·Yujiro ItoSamson W Fine
Jul 16, 2017·Cold Spring Harbor Perspectives in Medicine·Eric T MillerRobert E Reiter
Oct 30, 2020·The International Journal of Biostatistics·Katharina SeligDonna Ankerst
Mar 19, 2021·The International Journal of Biochemistry & Cell Biology·Chunlei ZhangDehui Chang
Jul 28, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Nikolaos GrivasHenk G van der Poel

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