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Do anesthetics act by competitive binding to specific receptors? Phase transition of firefly luciferase

Toxicology Letters

Nov 23, 1998

Issaku UedaHiroshi Kamaya

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Abstract

1. Firefly luciferase (FFL) emits a flash of light when mixed with ATP and luciferin in the presence of molecular oxygen. 2. Halothane inhibited FFL at 0.22 mM, while myristic acid inhibited it at 0.68 microM. Under steady-state conditions, myristic acid competed with luciferin. The Lin...read more

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  • Do anesthetics act by competitive binding to specific receptors? Phase transition of firefly luciferase

    Toxicology Letters

    Nov 23, 1998

    Issaku UedaHiroshi Kamaya

    PMID: 10049172

    DOI: 10.1016/s0378-4274(98)00214-8

    Abstract

    1. Firefly luciferase (FFL) emits a flash of light when mixed with ATP and luciferin in the presence of molecular oxygen. 2. Halothane inhibited FFL at 0.22 mM, while myristic acid inhibited it at 0.68 microM. Under steady-state conditions, myristic acid competed with luciferin. The Lin...read more

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