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Do anesthetics act by competitive binding to specific receptors? Phase transition of firefly luciferase

Toxicology Letters

Feb 27, 1999

I UedaH Kamaya

Abstract

1. Firefly luciferase (FFL) emits a flash of light when mixed with ATP and luciferin in the presence of molecular oxygen. 2. Halothane inhibited FFL at 0.22 mM, while myristic acid inhibited it at 0.68 microM. Under steady-state conditions, myristic acid competed with luciferin. The Lin...read more

Mentioned in this Paper

Halothane
Macromolecular Alteration
Luciferases, Firefly
Acylation
Receptors, Drug
Plasma Protein Binding Capacity
Ligand Binding Domain
Contrast Used
Anesthesiology
5'-Adenylic Acid
Paper Details
References
  • References21
  • Citations2
123

Do anesthetics act by competitive binding to specific receptors? Phase transition of firefly luciferase

Toxicology Letters

Feb 27, 1999

I UedaH Kamaya

PMID: 10049172

DOI: 10.1016/s0378-4274(98)00214-8

Abstract

1. Firefly luciferase (FFL) emits a flash of light when mixed with ATP and luciferin in the presence of molecular oxygen. 2. Halothane inhibited FFL at 0.22 mM, while myristic acid inhibited it at 0.68 microM. Under steady-state conditions, myristic acid competed with luciferin. The Lin...read more

Mentioned in this Paper

Halothane
Macromolecular Alteration
Luciferases, Firefly
Acylation
Receptors, Drug
Plasma Protein Binding Capacity
Ligand Binding Domain
Contrast Used
Anesthesiology
5'-Adenylic Acid

Related Papers

Paper Details
References
  • References21
  • Citations2
123
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