Do animal models have clinical value?

The American Journal of Cardiology
P J Schwartz

Abstract

This article examines the efficacy of studying antiarrhythmic and antifibrillatory interventions using animal models. The importance of identifying appropriate animal models and comparing results from these studies to human clinical trials is discussed. Specific studies will be cited, the advantages/disadvantages of each design (i.e., internal control analysis factors, reproducibility of results, anesthetized vs conscious models) will be presented, and their ability or inability to predict clinical outcomes will be discussed.

References

Jul 23, 1992·The New England Journal of Medicine·UNKNOWN Cardiac Arrhythmia Suppression Trial II Investigators
Aug 18, 1988·The New England Journal of Medicine·UNKNOWN Multicenter Diltiazem Postinfarction Trial Research Group
Nov 1, 1984·Journal of Cardiovascular Pharmacology·J J LynchB R Lucchesi

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Citations

Oct 15, 2011·Cells, Tissues, Organs·Donald O FreytesGordana Vunjak-Novakovic
Feb 16, 2012·Circulation. Arrhythmia and Electrophysiology·George E BillmanPeter J Schwartz
Aug 30, 2003·American Heart Journal·Raffaele De CaterinaMaria Teresa La Rovere
Feb 5, 2008·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Emilio VanoliPeter J Schwartz
Oct 19, 2004·Journal of the American College of Cardiology·Philip B AdamsonEmilio Vanoli
Nov 11, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Peter J Schwartz, Gaetano M De Ferrari
Apr 14, 2000·Circulation Research·J M CaoP S Chen
Jun 21, 2017·Circulation. Arrhythmia and Electrophysiology·Yingxin LiJoseph C Wu
Sep 15, 2005·Journal of Cardiovascular Pharmacology·Arnfinn IlebekkMargareta Nordlander
Jun 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Joseph J LynchDavid A Claremon
Apr 30, 2003·Journal of Cardiovascular Pharmacology·Philip B AdamsonPeter J Schwartz
Mar 2, 1999·Journal of Computer Assisted Tomography·H D GageJ C Eisenach
Jun 18, 2021·World Journal of Stem Cells·Steven B KarchMassimo Volpe

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