Do Antibiotics Reduce the Incidence of Infections After Percutaneous Endoscopic Gastrostomy Placement in Children?

Journal of Pediatric Gastroenterology and Nutrition
Hilde KromAngelika Kindermann

Abstract

Percutaneous endoscopic gastrostomy (PEG) provides a long-term solution for tube dependency. Pediatric guidelines recommend prophylactic antibiotic treatment (ABT) based on adult studies. To compare wound infection and other complications in children receiving a PEG with and without prophylactic ABT. Retrospective study including children 0 to 18 years undergoing PEG placement. Patients with (2010-2013) and without (2000-2010) ABT were compared with respect to the occurrence of wound infection and other complications. In total, 297 patients were included (median age 2.9 years, 53% boys). Patients receiving ABT per PEG protocol (n = 78) had a similar wound infection rate (17.9% vs 21%, P = 0.625), significantly less fever (3.8% vs 14.6%, P = 0.013), leakage (0% vs 9.1%, P = 0.003) and shorter hospital admission (2 vs 4 days, P = 0.000), but more overgranulation (28.2% vs 8.7%, P = 0.000) compared with those without (n = 219). Patients receiving any ABT, per PEG protocol or clinical indication (n = 115), had similar occurrence of wound infection (19.1% vs 20.9%, P = 0.768), fever (7.8% vs 14.3%, P = 0.100) and leakage (3.5% vs 8.8%, P = 0.096), a significantly shorter hospital admission (3 vs 4 days, P = 0.000), but more overgran...Continue Reading

References

Dec 1, 1980·Journal of Pediatric Surgery·M W GaudererR J Izant
Feb 24, 1998·Journal of Pediatric Surgery·I U KhattakL Spitz
Nov 8, 2001·Journal of Pediatric Gastroenterology and Nutrition·E M Mathus-VliegenC G Moorman-Voestermans
Feb 9, 2005·Journal of Pediatric Gastroenterology and Nutrition·D RawatM Thomson
Feb 25, 2010·Journal of Pediatric Gastroenterology and Nutrition·John E FortunatoKathleen B Schwarz
May 11, 2010·Journal of Pediatric Gastroenterology and Nutrition·Christian BraeggerJohannes van Goudoever
May 1, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Francesco Fascetti-LeonPietro Betalli
Jun 1, 2013·Pediatrics and Neonatology·Fu-Yu WuYen-Hsuan Ni
Jun 27, 2013·Journal of Pediatric Gastroenterology and Nutrition·Ali IslekReha Artan
Nov 2, 2013·Journal of Pediatric Gastroenterology and Nutrition·Maireade E McSweeneyJenifer R Lightdale
Jul 16, 2014·Journal of Pediatric Gastroenterology and Nutrition·R B HeuschkelY Vandenplas
Sep 23, 2014·Pediatrics International : Official Journal of the Japan Pediatric Society·Guido EngelmannUlrike Teufel
Feb 6, 2015·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Margrét Brands ViktorsdóttirLuther Sigurdsson
May 14, 2016·Pediatric Radiology·Leema DookhooBairbre L Connolly
Oct 4, 2016·American Journal of Human Genetics·Vandana ShashiFanny Kortüm
Apr 13, 2017·Pediatric Gastroenterology, Hepatology & Nutrition·June KimSun Jun Kim
Feb 20, 2018·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Hilde KromAngelika Kindermann
Nov 9, 2018·Tissue Barriers·Ashfaqul Alam, Andrew Neish

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Citations

Nov 6, 2020·Journal of Pediatric Gastroenterology and Nutrition·Francesco AlessandriGiovanni Di Nardo

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