Do bednets including piperonyl butoxide offer additional protection against populations of Anopheles gambiae s.l. that are highly resistant to pyrethroids? An experimental hut evaluation in Burkina Fasov

Medical and Veterinary Entomology
Kobié H ToéHilary Ranson

Abstract

Malaria control is dependent on the use of longlasting insecticidal nets (LLINs) containing pyrethroids. A new generation of LLINs containing both pyrethroids and the synergist piperonyl butoxide (PBO) has been developed in response to increasing pyrethroid resistance in African malaria vectors, but questions remain about the performance of these nets in areas where levels of pyrethroid resistance are very high. This study was conducted in two settings in southwest Burkina Faso, Vallée du Kou 5 and Tengrela, where Anopheles gambiae s.l. (Diptera: Culicidae) mortality rates in World Health Organization (WHO) discriminating dose assays were < 14% for permethrin and < 33% for deltamethrin. When mosquitoes were pre-exposed to PBO in WHO tube assays, mortality rates increased substantially but full susceptibility was not restored. Molecular characterization revealed high levels of kdr alleles and elevated levels of P450s previously implicated in pyrethroid resistance. In cone bioassays and experimental huts, PBO LLINs outperformed the pyrethroid-only equivalents from the same manufacturers. Blood feeding rates were 1.6-2.2-fold lower and mortality rates were 1.69-1.78-fold greater in huts with PBO LLINs vs. non-PBO LLINs. This study...Continue Reading

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Citations

Nov 30, 2018·The Cochrane Database of Systematic Reviews·Katherine GleaveHilary Ranson
Apr 14, 2020·International Journal of Environmental Health Research·Elvire Mfueni Bikundi, Yves Coppieters
Dec 4, 2019·Nature Microbiology·Gregory P D MurrayPhilip J McCall
Jun 6, 2019·Parasites & Vectors·Kevin Ochieng' OpondoUmberto D'Alessandro
Sep 12, 2020·Parasites & Vectors·Eunice Oluwatobiloba AdedejiEzekiel Adebiyi
Dec 27, 2019·Nature·Victoria A InghamHilary Ranson
May 25, 2020·Journal of Mathematical Biology·Iboi EnahoroKrijn Paaijmans
Jan 9, 2021·Malaria Journal·Jeff JonesPhilip J McCall
May 25, 2021·The Cochrane Database of Systematic Reviews·Katherine GleaveHilary Ranson

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