PMID: 2502133Jun 1, 1989Paper

Do CD4 and CD8 control T-cell activation via a specific tyrosine protein kinase?

Immunology Today
T Mustelin, A Altman

Abstract

The CD4 and CD8 glycoproteins play an important role in T-cell activation by binding to major histocompatibility complex (MHC) class II or class I molecules, respectively, and stabilizing their interactions with the T-cell receptor-CD3 complex during antigen presentation. Recent evidence suggesting that the cytoplasmic domains of CD4 and CD8 are physically, and perhaps functionally, linked to the T-cell specific tyrosine protein kinase, p56lck, adds a new dimension to our current understanding of their physiological function. Based on these and other recent findings, Tomas Mustelin and Amnon Altman present a working hypothesis that defines a novel role for CD4 or CD8 in regulating T-cell activation, and perhaps other processes, such as thymic repertoire selection and human immunodeficiency virus (HIV)-induced immunosuppression.

References

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Citations

Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T MustelinA Altman
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·N OyaizuS Pahwa
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·B HofmannJ L Fahey
Jun 1, 1995·Journal of Toxicology and Environmental Health·D R DavilaS W Burchiel
Aug 1, 1993·AIDS Research and Human Retroviruses·A G Laurent-CrawfordA G Hovanessian
Feb 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Q LiP Fitzgerald-Bocarsly
Sep 1, 1991·Scandinavian Journal of Immunology·T Mustelin, A Altman
Apr 30, 1990·European Journal of Biochemistry·N Berry, Y Nishizuka
Apr 14, 2005·European Journal of Immunology·Vibeke Sundvold-GjerstadTor Lea
Sep 28, 2007·The Journal of Biological Chemistry·Konstantina NikaTomas Mustelin
Jan 1, 1991·International Reviews of Immunology·P Lenert, M Zanetti
Apr 1, 1991·Immunological Investigations·M B Zaleski
Jan 1, 1991·Life Sciences·H M SmilowitzP M Epstein
Jun 1, 1993·Trends in Biochemical Sciences·T Mustelin, P Burn

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