Do changes in cardiac output affect the inspiratory to end-trial oxygen difference?

Acta Anaesthesiologica Scandinavica
J BengtssonJ P Bengtson

Abstract

The paramagnetic technique has made it possible to monitor the end-tidal oxygen concentration and P(1-ET)O2, i.e. inspiratory to end-tidal oxygen difference, breath-by-breath. Little is known about the implications of a changing P(1-ET)O2, but so far studies have shown it to be a quick and sensitive variable to detect hypoventilation. This study was designed to observe the circulatory effects on P(1-ET)O2 in an experimental setting but monitored as in a clinical situation. We assessed the oxygen difference during changes in cardiac output induced by intravenous ephedrine-hydrochloride in 12 healthy male volunteers. P(1-ET)O2 was measured with a fast-response paramagnetic differential oxygen sensor. Cardiac output was measured with non-invasive transthoracic electrical bioimpedance. As simultaneous changes in metabolism and ventilation will also influence P(1-ET)O2 oxygen uptake and expired minute volume were monitored. After a rest period, the subjects had an intravenous injection of ephedrine-hydrochloride 0.1 mg.kg-1 followed by a 30-min observation period. Cardiac output increased significantly as did the oxygen uptake and the ventilation. We found no biological significant correlation between cardiac output and P(1-ET)O2. T...Continue Reading

References

Jun 1, 1992·British Journal of Anaesthesia·J P BengtsonO Stenqvist
Dec 1, 1991·Anesthesia and Analgesia·S A Isserles, P H Breen
Jan 1, 1990·Journal of Clinical Monitoring·P T Meriläinen
Jan 1, 1988·International Journal of Clinical Monitoring and Computing·P T Meriläinen
Jan 1, 1987·International Journal of Clinical Monitoring and Computing·P T Meriläinen
Nov 1, 1985·Critical Care Medicine·M H WeilE C Rackow
Aug 1, 1994·British Journal of Anaesthesia·J BengtssonJ P Bengtson

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Citations

Nov 1, 1995·Acta Anaesthesiologica Scandinavica·M RådströmJ P Bengtson
Feb 6, 1998·International Journal of Clinical Monitoring and Computing·J Bengtsson, J P Bengtson

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