Do clinical data and human papilloma virus genotype influence spontaneous regression in grade I cervical intraepithelial neoplasia?

Journal of the Turkish German Gynecological Association
Caterina Cortés-AlagueroEnrique Poblet-Martinez

Abstract

To determine whether medical history, clinical examination and human papilloma virus (HPV) genotype influence spontaneous regression in cervical intraepithelial neoplasia grade I (CIN-I). We retrospectively evaluated 232 women who were histologically diagnosed as have CIN-I by means of Kaplan-Meier curves, the pattern of spontaneous regression according to the medical history, clinical examination, and HPV genotype. Spontaneous regression occurred in most patients and was influenced by the presence of multiple HPV genotypes but not by the HPV genotype itself. In addition, regression frequency was diminished when more than 50% of the cervix surface was affected or when an abnormal cytology was present at the beginning of follow-up. The frequency of regression in CIN-I is high, making long-term follow-up and conservative management advisable. Data from clinical examination and HPV genotyping might help to anticipate which lesions will regress.

Citations

May 18, 2021·Frontiers in Public Health·Jacqueline Cortinhas MonteiroLuiz Fernando Almeida Machado
Jun 29, 2021·Journal of Lower Genital Tract Disease·Diede L LoopikJames R Bentley

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Methods Mentioned

BETA
genotyping
biopsy
contraception
PCR

Software Mentioned

Graph Pad Prism
Graph Pad

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