Do Clopidogrel Nonresponders Have an Increased Risk of Adverse Events during Supra-Aortal Angioplasty and Stenting?

Stroke Research and Treatment
Heiko KoernerWolfgang Reith

Abstract

Objective. The aim of the present study was to correlate new periprocedural diffusion-weighted imaging (DWI) lesions during stenting of supra-aortal arteries with the level of platelet inhibition using point-of-care analysis. Background. Cardiological studies have shown that patients undergoing coronary PTA have a significantly elevated risk of severe thrombotic complications if patients show insufficient inhibition of platelet function. Methods. From August 2008 to June 2009, 44 patients with an indication of supra-aortal angioplasty and/or stenting were prospectively enrolled. Platelet reactivity was tested using a Multiplate device (Dynabyte). These patients underwent MRI before and after the intervention to determine the prevalence of new DWI lesions. The primary endpoint was the prevalence of DWI lesions; the secondary endpoint was clinical status until discharge from hospital. Results. There was no significant relationship between the primary endpoint and the degree of platelet function. Patients with high platelet reactivity showed the same amount of periprocedural complications as patients with sufficient inhibition of platelets. Conclusions. Clopidogrel did not have a protective effect on periprocedural complications, ...Continue Reading

References

Jun 7, 2005·Journal of the American College of Cardiology·Peter WenaweserOtto M Hess
Nov 16, 2005·Journal of the American College of Cardiology·Paul A GurbelUdaya S Tantry
Aug 5, 2006·Stroke; a Journal of Cerebral Circulation·Andreas KastrupUlrike Ernemann
Aug 12, 2008·Thrombosis and Haemostasis·Antonio De MiguelJuan José Badimón
Dec 25, 2008·The New England Journal of Medicine·Jessica L MegaMarc S Sabatine
Feb 10, 2009·Neuroradiology·I Q GrunwaldW Reith
Mar 7, 2009·Journal of the American College of Cardiology·Dirk SibbingNicolas von Beckerath
Mar 3, 2010·Circulation·Luke TappGregory Y H Lip
Sep 11, 2010·Journal of the American College of Cardiology·Laurent BonelloUNKNOWN Working Group on High On-Treatment Platelet Reactivity

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Citations

Dec 2, 2017·Journal of Neurosurgery·Keri S KimAaron M Cook
Jan 12, 2019·Journal of Korean Neurosurgical Society·Ho Jun YiByoung Hun Lee

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Methods Mentioned

BETA
percutaneous transluminal coronary angioplasty
percutaneous transluminal angioplasty

Software Mentioned

Multiplate
RESPOND
SPSS

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