PMID: 11907946Mar 23, 2002Paper

Do combinations of 1 mg estradiol and low doses of NETA effectively control menopausal symptoms?

Climacteric : the Journal of the International Menopause Society
U BaerugJ C Arce

Abstract

This study compared two continuous-combined hormone replacement therapy (HRT) formulations, 1 mg estradiol (E2)/0.25 mg norethisterone acetate (NETA) and 1 mg E2/0.5 mg NETA, with placebo, with regard to the efficacy for vasomotor symptom relief in menopausal women. A total of 119 women aged 45-61 years with moderate and severe hot flushes and with amenorrhea for at least 3 months were randomly assigned to 12 weeks' treatment with 1 mg E2/0.25 mg NETA, 1 mg E2/0.5 mg NETA or placebo. The number and severity of hot flushes, as well as any vaginal bleeding, were recorded on a daily basis. The Kupperman Menopausal Index, Greene Climacteric Scale and visual analog scales for various symptoms were assessed before and after treatment. Subpopulation analysis according to menopausal status was performed. Both combinations significantly reduced the number and severity of hot flushes, compared to placebo. A reduction of approximately 85% in vasomotor symptomatology occurred in the two combination groups by week 4 of treatment, and this was further diminished throughout the study to approximately 97% reduction by week 12. At the end of the study, 85% of the women receiving 1 mg E2/0.5 mg NETA and 71% of the women receiving 1 mg E2/0.25 mg...Continue Reading

References

Jan 1, 1976·Journal of Psychosomatic Research·J G Greene
Jul 11, 1975·Obstetrics and Gynecology·M R CallantineM O Greaney
Feb 1, 1991·The Journal of Clinical Endocrinology and Metabolism·B B Sherwin
Oct 1, 1988·British Journal of Obstetrics and Gynaecology·T SporrongL A Mattsson
Jan 1, 1984·Acta Obstetricia Et Gynecologica Scandinavica·M FuruhjelmK Carlström
Jul 19, 1980·British Medical Journal·G T BungayC K McPherson
Oct 2, 1993·BMJ : British Medical Journal·E DalyM Vessey
Mar 1, 1993·American Journal of Obstetrics and Gynecology·A OldenhaveW T Everaerd
Jun 1, 1953·The Journal of Clinical Endocrinology and Metabolism·H S KUPPERMANW FILLER

❮ Previous
Next ❯

Citations

Oct 20, 2006·Archives of Gynecology and Obstetrics·Semih TugrulSadiye Eren
Mar 7, 2003·Fertility and Sterility·Cairu LiAnders Aberg
Apr 25, 2000·Obstetrics and Gynecology·M NotelovitzJ Arce
Feb 12, 2002·Maturitas·Foo Hoe LohLars Nellemann Jorgensen
Jul 5, 2005·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Debi SmolinskiLinda S Kim
Sep 10, 2002·Menopause : the Journal of the North American Menopause Society·Göran SamsioeSören Larsen
Sep 16, 2008·Menopause : the Journal of the North American Menopause Society·M Diana van DieHelena J Teede
Mar 2, 2011·Menopause : the Journal of the North American Menopause Society·Rafael Bolaños-DíazJosé Francia-Romero
Nov 1, 2003·Journal of Women's Health·Carolyn Crandall
May 11, 2005·Expert Opinion on Investigational Drugs·Darlene C Deecher
Jul 20, 2007·Taiwanese Journal of Obstetrics & Gynecology·Peng-Hui WangKuan-Chong Chao
Jun 7, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Daniela RouskovaThomas Zimmermann
May 1, 2004·American Journal of Obstetrics and Gynecology·Michelle P Warren
Sep 19, 2000·American Journal of Obstetrics and Gynecology·N H BjarnasonC Christiansen
Jan 6, 2000·Hospital Medicine·D W Sturdee
Oct 21, 2004·The Cochrane Database of Systematic Reviews·A H MaclennanV Moore
Nov 12, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Winfried G Rossmanith, Wiebke Ruebberdt
Oct 1, 2019·Menopause : the Journal of the North American Menopause Society·Marie K ChristakisWen Shen
Jun 17, 2003·Clinical Obstetrics and Gynecology·David F Archer
Oct 2, 2002·Obstetrics and Gynecology Clinics of North America·Andrew M Kaunitz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.