Do cross-modal projections always result in multisensory integration?

Cerebral Cortex
Brian L AllmanM Alex Meredith

Abstract

Convergence of afferents from different sensory modalities has generally been thought to produce bimodal (and trimodal) neurons (i.e., exhibit suprathreshold excitation to more than 1 sensory modality). Consequently, studies identifying cross-modal connections assume that such convergence results in bimodal (or trimodal) neurons that produce familiar forms of multisensory integration: response enhancement or depression. The present study questioned that assumption by anatomically identifying a projection from ferret auditory to visual cortex Area 21. However, electrophysiological recording within Area 21 not only failed to identify a single bimodal neuron but also familiar forms of multisensory integration were not observed either. Instead, a small proportion of neurons (9%; 27/296) showed subthreshold multisensory integration, in which visual responses were significantly modulated by auditory inputs. Such subthreshold multisensory effects were enhanced by gamma-aminobutyric acid antagonism, whereby a majority of neurons (87%; 20/23) now participated in a significant, multisensory population effect. Thus, multisensory convergence does not de facto result in bimodal (or trimodal) neurons or the traditional forms of multisensory ...Continue Reading

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Citations

Jan 21, 2010·Experimental Brain Research·Leslie P KenistonM Alex Meredith
Apr 12, 2012·Cognitive Neuropsychology·Sebastian J Crutch, Elizabeth K Warrington
Dec 6, 2008·Neuroreport·M Alex Meredith, Brian L Allman
Oct 4, 2012·NeuroImage·Sascha TyllTömme Noesselt
Jan 22, 2008·Cerebral Cortex·Brian L AllmanM Alex Meredith
Jan 3, 2013·The European Journal of Neuroscience·W Alex FoxworthyM Alex Meredith
Jul 12, 2012·The European Journal of Neuroscience·Valérie CharbonneauDenis Boire
Nov 23, 2012·The Journal of Comparative Neurology·W Alex FoxworthyM Alex Meredith
Mar 3, 2015·The European Journal of Neuroscience·M Alex Meredith, Brian L Allman
Nov 30, 2013·Neural Plasticity·Yu-Ting Mao, Sarah L Pallas
Jan 9, 2013·NeuroImage·Benjamin de HaasGeraint Rees
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Mar 24, 2009·Hearing Research·M Alex MeredithH Ruth Clemo
May 19, 2009·Trends in Amplification·Rosalie M UchanskiRichard A Chole
Jan 26, 2017·Frontiers in Behavioral Neuroscience·Ashley L SchormansBrian L Allman

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