Do current approaches to assessing therapy related adverse events align with the needs of long-term cancer patients and survivors?

Cardio-Oncology
Syril D Pettit, Rebecca A Kirch

Abstract

The increasing efficacy of cancer therapeutics means that the timespan of cancer therapy administration is undergoing a transition to increasingly long-term settings. Unfortunately, chronic therapy-related adverse health events are an unintended, but not infrequent, outcome of these life-saving therapies. Historically, the cardio-oncology field has evolved as retrospective effort to understand the scope, mechanisms, and impact of treatment-related toxicities that were already impacting patients. This review explores whether current systemic approaches to detecting, reporting, tracking, and communicating AEs are better positioned to provide more proactive or concurrent information to mitigate the impact of AE's on patient health and quality of life. Because the existing tools and frameworks for capturing these effects are not specific to cardiology, this study looks broadly at the landscape of approaches and assumptions. This review finds evidence of increasing focus on the provision of actionable information to support long-term health and quality of life for survivors and those on chronic therapy. However, the current means to assess and support the impact of this burden on patients and the healthcare system are often of limit...Continue Reading

References

Dec 18, 2003·British Journal of Clinical Pharmacology·Karin MartinNicholas Moore
Jan 21, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M MartyUNKNOWN Dexrazoxane Study Group
Feb 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Allison W KurianAlan M Garber
May 30, 2007·Clinical Drug Investigation·Samuel LimatMarie-Christine Woronoff-Lemsi
Sep 18, 2007·Gynecologic Oncology·Laura J HavrileskyEvan Myers
Sep 13, 2008·Nature Reviews. Drug Discovery·Hans-Georg EichlerAlasdair Breckenridge
Nov 7, 2008·Cancer·Neal J MeropolUNKNOWN CONNECT Study Research Group
Mar 25, 2009·Cancer·Yu-Ning WongJ Robert Beck
Apr 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leslie L RobisonLonnie K Zeltzer
Jun 10, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Amin HaideraliJessica Wegner
Jun 29, 2010·Health Expectations : an International Journal of Public Participation in Health Care and Health Policy·Simron SinghMartin H N Tattersall
Oct 16, 2010·Nature Medicine·Clifford J Woolf
Sep 15, 2011·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Bernardo Goulart, Scott Ramsey
Oct 8, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·K Robin YabroffAngela Mariotto
Mar 2, 2012·The New England Journal of Medicine·Michael J Barry, Susan Edgman-Levitan
May 24, 2012·International Journal of Technology Assessment in Health Care·Sonja V SorensenShrividya Iyer
Jul 4, 2012·Nature Reviews. Clinical Oncology·Charles S CleelandJamey Skillings
Oct 6, 2012·Mayo Clinic Proceedings·Mustaqeem Siddiqui, S Vincent Rajkumar
Jan 15, 2013·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Mehmet U S AyvaciSam J Lubner
Jul 17, 2013·CA: a Cancer Journal for Clinicians·Julie K SilverR Samuel Mayer
Aug 15, 2013·Journal of Oncology Practice·Rebecca M SpeckAngela DeMichele
Sep 26, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julien PéronBenoit You
Oct 16, 2013·International Journal of Cancer. Journal International Du Cancer·Matteo SantoniStefano Cascinu
Oct 17, 2013·Applied Health Economics and Health Policy·Alison PearceRosalie Viney
Oct 30, 2013·Nature Reviews. Clinical Oncology·Steven E LipshultzTracie L Miller
Mar 19, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gregory T ArmstrongKevin C Oeffinger
Apr 4, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Alison ZuccaMariko Carey
Apr 11, 2014·Journal of Medical Economics·Preeti S BajajJosh J Carlson
May 29, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicole M Kuderer, Antonio C Wolff
Oct 1, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Saroj NiraulaIan F Tannock
Jan 7, 2015·Journal of Managed Care & Specialty Pharmacy·Thomas E DeleaMichelle D Hackshaw
Jan 17, 2015·Journal of the American Academy of Dermatology·James B MacdonaldAleksandar Sekulic
Feb 11, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amanda J Redig, Pasi A Jänne
Jun 23, 2015·International Journal of Applied & Basic Medical Research·Rajiv Mahajan

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