Do cytokines correlate with refractory Kawasaki disease in children?

Clinica Chimica Acta; International Journal of Clinical Chemistry
Ying WangZhen Zhen

Abstract

Kawasaki disease (KD) is a type of pediatric vasculitis. Ten to twenty percent of children with KD do not respond to initial intravenous immunoglobulin (IVIG) treatment which called refractory Kawasaki disease. If untreated, approximately 15-25% of KD patients have complications. Therefore, it is important to predict whether KD is resistant to IVIG at an early stage. The aim of this study was to determine whether cytokines are predictors of refractory KD in children. We retrospectively reviewed the medical records of 265 children diagnosed with KD who received IVIG within 10 days of fever onset at Beijing Children's Hospital. Refractory Kawasaki disease was defined as persistent or recrudescent fever beyond 36 h after IVIG. Before IVIG and 3 days after temperature normalization following IVIG treatment, the concentrations of cytokines in the serum including interferon gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), interleukin-6 (IL-6), interleukin-4 (IL-4), interleukin-2 (IL-2) and other conventional inflammatory mediators including white blood cells counts (WBC), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and albumin were detected. The patients were divided into 2 groups: IVIG-s...Continue Reading

Citations

Sep 16, 2020·The Pediatric Infectious Disease Journal·Milena De PaulisEliane Roseli Barreira
Mar 16, 2021·Indian Journal of Clinical Biochemistry : IJCB·Manjari Basu, Subir Kumar Das
Aug 6, 2021·Frontiers in Pediatrics·Lung ChangKuender D Yang
Aug 8, 2021·Journal of Clinical Medicine·Perrine Dusser, Isabelle Koné-Paut

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