Do dehydroepiandrosterone, progesterone, and testosterone influence women's depression and anxiety levels? Evidence from hair-based hormonal measures of 2105 rural Indian women

Psychoneuroendocrinology
Andreas WaltherL Berkman

Abstract

Depressive and anxiety disorders substantially contribute to the global burden of disease, particularly in poor countries. Higher prevalence rates for both disorders among women indicate sex hormones may be integrated in the pathophysiology of these disorders. The Kshetriya Gramin Financial Services study surveyed a random sample of 4160 households across 876 villages in rural Tamil Nadu, India. An interviewer-administered questionnaire was conducted to quantify depressive (K6-D) and anxiety (K6-A) symptoms. Alongside, hair samples for sex hormone profiling were collected from a subsample of 2105 women aged 18-85 years. Importantly, 5.9%, 14.8%, and 46.3% of samples contained non-detectable hormone levels for dehydroepiandrosterone, progesterone, and testosterone, respectively. Our primary analysis imputes values for the non-detectable sample and we check robustness of results when non-detectable values are dropped. In this cohort of women from rural India, higher depressive symptomatology is associated with lower levels of dehydroepiandrosterone and higher depressive and anxiety symptoms are associated with higher levels of testosterone. Progesterone shows no clear association with either depressive or anxiety symptoms. These ...Continue Reading

References

Jan 1, 1977·Archives of General Psychiatry·M M Weissman, G L Klerman
Nov 14, 1997·Obstetrics and Gynecology·A J RapkinV B Mahesh
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·V UzunovaA Guidotti
Feb 18, 1999·The Journal of Clinical Endocrinology and Metabolism·E Barrett-ConnorD Kritz-Silverstein
Jul 14, 1999·Journal of Affective Disorders·L V ScottT G Dinan
Sep 30, 1999·The New England Journal of Medicine·W ArltB Allolio
Feb 26, 2000·Forensic Science International : Synergy·R Wennig
Feb 13, 2003·Archives of General Psychiatry·Ronald C KesslerAlan M Zaslavsky
Mar 21, 2003·Journal of Affective Disorders·Ronald C Kessler
Sep 23, 2003·Menopause : the Journal of the North American Menopause Society·Rebecca GoldstatSusan R Davis
Feb 9, 2005·Archives of General Psychiatry·Peter J SchmidtDavid R Rubinow
Apr 9, 2005·Journal of the American Geriatrics Society·Guy G T'SjoenJean-Marc Kaufman
Apr 21, 2005·The Journal of Clinical Endocrinology and Metabolism·Nanette SantoroGerson Weiss
Jan 5, 2006·The American Journal of Psychiatry·Judith G RabkinStephen J Ferrando
Dec 25, 2007·Gender Medicine·Marrie H J Bekker, Janneke van Mens-Verhulst
Mar 5, 2008·Archives of General Psychiatry·Osvaldo P AlmeidaLeon Flicker
Jul 26, 2008·Annual Review of Psychology·John W Graham
Sep 26, 2008·Psychological Science·Jon K ManerLisa A Eckel
Dec 10, 2008·Frontiers in Neuroendocrinology·Nicole ManingerSynthia H Mellon
Jun 18, 2010·The New England Journal of Medicine·Frederick C W WuUNKNOWN EMAS Group
Oct 7, 2010·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Linnea Hergot BerglundJohan Svartberg
Jan 1, 2010·Indian Journal of Psychiatry·J K Trivedi, Pawan Kumar Gupta
Mar 1, 2012·Brain, Behavior, and Immunity·Tobias Stalder, Clemens Kirschbaum
Apr 16, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Wei GaoClemens Kirschbaum
Sep 21, 2013·International Journal of Psychiatry in Clinical Practice·Panagiotis OulisManolis Markianos
Nov 13, 2013·Progress in Neurobiology·Cornelius SchüleRainer Rupprecht
Feb 21, 2014·International Journal of Psychiatry in Medicine·Hisashi MatsuzakaHeii Arai
Dec 3, 2014·Biological Psychiatry·Robert-Paul JusterJens C Pruessner
Dec 30, 2014·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Nicola VeroneseGiuseppe Sergi
Jul 2, 2015·The Journal of Sexual Medicine·Christopher J WestleyMichael S Irwig
Jan 1, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Wei GaoTobias Stalder
Mar 19, 2016·Frontiers in Neuroendocrinology·Rand MahmoudLiisa A M Galea
Apr 24, 2016·Social Psychiatry and Psychiatric Epidemiology·Rahul ShidhayeVikram Patel
May 23, 2016·Psychoneuroendocrinology·Kristina M DeligiannidisScott A Shaffer
Jun 28, 2016·Comprehensive Physiology·Crystal Edler SchillerDavid R Rubinow

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Citations

Jul 14, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·A WaltherC Kirschbaum
Mar 7, 2021·International Journal of Environmental Research and Public Health·Jongmin ParkChang Won Won

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