Do DNA copy number changes differentiate uterine from non-uterine leiomyosarcomas and predict metastasis?

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Catarina SvarvarSakari Knuutila

Abstract

DNA copy number changes were investigated in 51 (19 uterine and 32 nonuterine) primary leiomyosarcomas by comparative genomic hybridization. The aim was to evaluate whether true biological differences exist between uterine and nonuterine leiomyosarcoma and whether changes revealed by comparative genomic hybridization have prognostic value. Genomic imbalances were found in 48 (94%) cases. The most frequent DNA copy number changes were losses in 10q (35%), 13q (57%), and 16q (41%), gains in 1q (41%), and gains and high-level amplifications in 17p (39%). Gains were nearly as frequent as losses in both uterine and nonuterine leiomyosarcoma. Correlation-based tree modeling revealed two clusters that segregated significantly a group of uterine (gains at 1q11-q24) and a group of nonuterine (losses at 13q14-q34, 16q11.1-q24, and 10q21-q26) cases. The nonuterine cluster was associated with subcutaneous origin and a trend toward increased metastasis-free survival. Further explorative analyses identified aberrations associated with shorter metastasis-free survival time, including losses at 2q32.1-q37 and gains at 8q24.1-q24.3, whereas the cases with losses at 6cen-p25 showed longer metastasis-free survival time.

References

Jan 1, 1991·Genes, Chromosomes & Cancer·B JohanssonF Mitelman
Aug 1, 1989·British Journal of Cancer·M R StrattonB R Reeves
Nov 1, 1989·Cancer Genetics and Cytogenetics·L BoghosianA A Sandberg
Oct 1, 1995·British Journal of Cancer·M S KarpehC Cordon-Cardo
Jun 1, 1994·The American Journal of Surgical Pathology·S W BellM R Hendrickson
Jun 1, 1994·British Journal of Cancer·H PattersonC S Cooper
Apr 1, 1997·Immunology Today·A M Weissman
May 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R R Nordal, S O Thoresen
Sep 23, 1997·The American Journal of Surgical Pathology·S KadduH P Soyer
Sep 15, 1998·The American Journal of Pathology·W El-RifaiM Miettinen
Mar 30, 1999·International Journal of Cancer. Journal International Du Cancer·M TarkkanenS Knuutila
Jul 10, 1999·International Journal of Cancer. Journal International Du Cancer·M WolfS Knuutila
Sep 17, 1999·The American Journal of Pathology·S KnuutilaY Zhu
Dec 22, 1999·Cancer Genetics and Cytogenetics·F ParenteC Turc-Carel
Jan 5, 2002·The American Journal of Surgical Pathology·Gelareh FarshidSharon W Weiss
Apr 12, 2002·International Journal of Cancer. Journal International Du Cancer·Ralf J RiekerGunhild Mechtersheimer
Jan 29, 2003·Cancer Genetics and Cytogenetics·Maaike van DartelTheo J M Hulsebos
Mar 1, 2003·Pathology International·Kimitaka MiyajimaMasazumi Tsuneyoshi
Aug 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rubin WangJanet Shipley
Aug 28, 2003·Cancer·Keith M Skubitz, Amy P N Skubitz
Sep 5, 2003·Breast Cancer : the Journal of the Japanese Breast Cancer Society·A Lakshmi KesariM Radhakrishna Pillai

❮ Previous
Next ❯

Citations

Apr 30, 2015·Journal of Surgical Oncology·David J WorhunskyGeorge A Poultsides
Dec 1, 2009·Surgical Pathology Clinics·Cheng-Han LeeC Blake Gilks
Feb 10, 2007·Expert Review of Anticancer Therapy·Joseph G Sinkovics
Nov 19, 2009·Acta Orthopaedica. Supplementum·Thor AlvegårdAnders Rydholm
Oct 25, 2017·International Journal of Cancer. Journal International Du Cancer·Tine CuppensFrédéric Amant
Jan 1, 2008·Gene Regulation and Systems Biology·Takuma HayashiIkuo Konishi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.