Do dyskinesia and pain share common pathophysiological mechanisms in Parkinson's disease?

Movement Disorders : Official Journal of the Movement Disorder Society
Shen-Yang LimAndrew H Evans

Abstract

Plastic changes within the striatum resulting from pulsatile dopaminergic stimulation are thought to lead to dyskinesia in patients with Parkinson's disease (PD). The basal ganglia play a role in processing pain. We hypothesized that the plastic changes that lead to dyskinesia may also mediate pain responses. Our objective was to compare the change in pain sensitivity after levodopa administration between stable responders, fluctuators without dyskinesia, and dyskinetic patients, and to compare pain sensitivity between PD and healthy subjects. Fifty patients with PD were assessed with cold water immersion after overnight withdrawal of dopaminergic medications and again after a standard levodopa challenge, and carefully classified into stable responder (n = 12), fluctuator (n = 15), and dyskinetic (n = 23) groups. Twenty age-matched controls were also tested. PD patients "off"-medication had a lower threshold (P = 0.016) and tolerance (P < 0.0001) to cold pain compared to controls. After levodopa administration, dyskinetic patients experienced a large increase in cold pain threshold (48%) and tolerance (66%) that was absent in stable responders (P = 0.038 and P = 0.015); there was no significant difference in pain sensitivity ch...Continue Reading

References

May 1, 1976·Neurology·S R SniderL J Cote
Oct 1, 1989·Annals of Neurology·D C GermanC B Saper
Jun 14, 1986·Lancet·N P QuinnC D Marsden
Jan 1, 1986·Movement Disorders : Official Journal of the Movement Disorder Society·C G GoetzD C Garron
Jan 1, 1987·Movement Disorders : Official Journal of the Movement Disorder Society·N QuinnC D Marsden
Jan 1, 1995·Pain·E H Chudler, W K Dong
Apr 1, 1997·Current Opinion in Neurobiology·W Schultz
Dec 22, 1999·Life Sciences·N Altier, J Stewart
May 24, 2000·Neurology·M ZappiaA Quattrone
Jul 12, 2002·Annals of Neurology·John G NuttGary J Sexton
Oct 23, 2002·Brain : a Journal of Neurology·Elena MoroPierre Pollak
Jan 18, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·C Marras, A E Lang
Feb 13, 2004·Brain : a Journal of Neurology·R H GracelyD J Clauw
Apr 13, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Andrew H EvansAndrew J Lees
Sep 25, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Regina KatzenschlagerAndrew J Lees
Feb 19, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Mark StacyFabrizio Stocchi
Feb 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Céline GuigoniErwan Bezard
Aug 4, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Christine Brefel-CourbonOlivier Rascol
Mar 22, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·M TinazziG Defazio
Mar 25, 2006·Annals of Neurology·Andrew H EvansPaola Piccini
Sep 8, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·John G Nutt
Oct 10, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Benjamin G ClissoldPeter A Kempster
Jul 24, 2007·NeuroImage·Luis Garcia-Larrea, Roland Peyron

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Citations

Nov 18, 2010·Journal of Neurology·Sandro Zambito MarsalaGiovanni Defazio
Dec 5, 2012·Journal of Neural Transmission·Giovanni DefazioMichele Tinazzi
May 12, 2011·PloS One·Volker HugeShahnaz Christina Azad
Feb 18, 2016·Current Neurology and Neuroscience Reports·Christian GeroinMichele Tinazzi
Apr 26, 2012·Expert Opinion on Emerging Drugs·Santiago Perez-LloretOlivier Rascol
Feb 18, 2016·Parkinson's Disease·Gwenda EngelsErik J A Scherder
Sep 7, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Cheng-Jie MaoChun-Feng Liu
Apr 23, 2016·Journal of Neurosurgery·Abigail BelasenJulie G Pilitsis
Aug 2, 2016·Expert Review of Neurotherapeutics·Antonio SuppaGiovanni Fabbrini
Sep 18, 2009·Journal of the Neurological Sciences·Carlos JuriJose A Obeso
Nov 2, 2016·Parkinson's Disease·Marcelo Rezende Young BloodCarlos Henrique Ferreira Camargo
Feb 19, 2017·Clinical Neurology and Neurosurgery·Petra Bago RožankovićMaristela Stojić
Feb 10, 2017·Ageing Research Reviews·Trevor ThompsonBrendon Stubbs
Mar 10, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A AntoniniO Rascol
Mar 31, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Shen-Yang LimAndrew H Evans
Jun 24, 2016·Movement Disorders Clinical Practice·Santiago Perez-LloretUNKNOWN Members of the MDS Committee on Rating Scales Development
Nov 26, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Carlos JuriJose A Obeso
Feb 27, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Shen-Yang Lim, Anthony E Lang
Jan 12, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Michele TinazziMassimiliano Valeriani
May 25, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Y GranovskyD Yarnitsky
Aug 9, 2015·Movement Disorders Clinical Practice·Veit MyliusJean-Pascal Lefaucheur
Jul 19, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Veit MyliusJens C Möller
Sep 29, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Ainhi D Ha, Joseph Jankovic
Dec 12, 2012·Neuromodulation : Journal of the International Neuromodulation Society·Andrea LandiErik Pietro Sganzerla
Jun 24, 2020·Journal of Neural Transmission·Christian GeroinMichele Tinazzi
Oct 15, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G DefazioA Berardelli
Apr 4, 2018·Neurotoxicity Research·G C NascimentoM Bortolanza
Jul 16, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Janne GierthmühlenRalf Baron
Feb 2, 2019·Journal of Neural Transmission·Estelle DellapinaChristine Brefel-Courbon
Feb 6, 2017·Movement Disorders Clinical Practice·Mayela Rodríguez-ViolanteK Ray Chaudhuri
Jul 7, 2015·European Journal of Pain : EJP·R G CuryD Ciampi de Andrade
Jan 12, 2021·Sexual Medicine·Claudia Marques Santa Rosa MalcherMarco de Tubino Scanavino
Oct 7, 2020·Revue neurologique·A Marques, C Brefel-Courbon
Jul 6, 2021·Drugs & Aging·Veit MyliusSantiago Perez Lloret

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