Do elevated blood levels of omega-3 fatty acids modify effects of particulate air pollutants on fibrinogen?

Air Quality, Atmosphere, & Health
Daniel CroftDavid Q Rich

Abstract

Previously, we found short-term increases in ambient particulate matter (PM) air pollutant concentrations were associated with increased serum fibrinogen levels in patients with cardiac disease. We now studied whether high blood levels of omega-3 (ω-3) fatty acids blunted this fibrinogen response to increased PM concentrations in these same patients. Plasma fibrinogen and ω-3 fatty acid levels (% of total identified fatty acids) were measured in blood samples collected from 135 patients treated at the University of Rochester Medical Center for myocardial infarction or stable ischemic heart disease requiring cardiac catheterization. Using ambient measurements of ultrafine, accumulation mode, and fine particles (PM2.5), Delta-C, and black carbon (BC), we regressed serum fibrinogen levels against pollutant concentrations over the previous 1-96 h, using interaction terms to estimate these associations separately for those with HIGH (> 5.12%) and LOWMED serum levels of ω-3 fatty acid (≤ 5.12%). Each 5.6 μg/m3 increase in PM2.5 concentration in the previous hour was associated with a 3.1% increase in fibrinogen (95% CI = 1.5%, 4.7%) in those subjects with LOWMED total ω-3 fatty acid levels, but only a 0.9% increase (95% CI = - 1.5%, ...Continue Reading

References

Feb 1, 1983·Journal of Clinical Pathology·C M ColleyM A Myers
Oct 8, 2005·American Journal of Respiratory and Critical Care Medicine·Isabelle RomieuFernando Holguin
Apr 28, 2007·American Journal of Respiratory and Critical Care Medicine·Kai-Jen ChuangChin-Sheng Tang
Jul 20, 2007·Environmental Health Perspectives·Regina RückerlUNKNOWN AIRGENE Study Group
Dec 11, 2007·The American Journal of Clinical Nutrition·William S HarrisPhilip G Jones
Dec 28, 2007·Atherosclerosis·William S HarrisErnst J Schaefer
Jun 9, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Robert S ChapkinDavid N McMurray
Aug 12, 2009·Lipids in Health and Disease·Breanne M Anderson, David W L Ma
May 12, 2010·Circulation·Robert D BrookUNKNOWN American Heart Association Council on Epidemiology and Prevention, Council on the Kidney in Cardiovascular Disease, and Coun
Nov 5, 2011·Journal of the American College of Cardiology·Dariush Mozaffarian, Jason H Y Wu
Aug 25, 2012·Journal of the Air & Waste Management Association·Yungang WangMark J Utell
May 15, 2013·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Robert C BlockS Georas
Nov 6, 2013·Circulation·H Robert SuperkoBrenda C Garrett
Dec 20, 2013·Journal of the American Heart Association·Marcia C de Oliveira OttoDariush Mozaffarian
Jan 4, 2015·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Robert C BlockShaker A Mousa
May 20, 2015·European Journal of Pharmacology·Dong-Soon Im
Jun 23, 2015·Lipid Technology·Oleksandr A ByelashovGunveen Kaur
Dec 2, 2015·Circulation·Ashish Chaddha, Kim A Eagle
Mar 16, 2017·Circulation·David S SiscovickUNKNOWN American Heart Association Nutrition Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Epidemiolo

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Methods Mentioned

BETA
enzyme-linked immunoassay

Software Mentioned

SAS

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