Abstract
We postulated that artifactually abnormal thallium-201 scans are well identified at the time of initial clinical interpretation by experienced readers and do not lead to unnecessary coronary angiography. Exercise thallium-201 scintigraphy employing quantitative imaging techniques has yielded sensitivity and specificity values of 80% to 90%. There are image artifacts, such as breast shadows, and variants of normal that, if not correctly identified, can lead to a high false positive rate for detection of coronary artery disease. Data from 338 consecutive patients with one or more focal thallium-201 defects on quantitative planar images were reviewed. All patients had undergone symptom-limited exercise scintigraphy and were classified as having either artifactual or nonartifactual thallium-201 defects after review of clinical reports. Of the 265 patients with defects judged to be nonartifactual on clinical readings, 167 underwent coronary angiography, which demonstrated significant coronary artery disease (> or = 50% stenosis) in 161 (96%) and normal findings in 6. Four of the latter six had documented prior myocardial infarction. The remaining 73 patients (85% female) had thallium-201 defects deemed to be artifactual on clinical ...Continue Reading
References
Apr 1, 1975·Circulation·W G AustenB B Roe
Nov 1, 1990·Annals of Internal Medicine·T S Kotler, G A Diamond
Feb 1, 1990·Journal of the American College of Cardiology·J J MahmarianM S Verani
May 1, 1988·Clinical Nuclear Medicine·J FriedmanJ Maddahi
Jan 1, 1985·Seminars in Nuclear Medicine·F J WackersJ P Clements
Mar 1, 1986·Journal of the American College of Cardiology·S KaulG M Pohost
Apr 1, 1985·The American Journal of Cardiology·F X PameliaG A Beller
Apr 1, 1974·Circulation·J W Linhart, H B Turnoff
Dec 1, 1984·Southern Medical Journal·L M PrisantA A Carr
Jul 1, 1984·Journal of the American College of Cardiology·T M BatemanD S Berman
Nov 1, 1981·Circulation·J MaddahiJ Forrester
Citations
Dec 14, 2005·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Yasmin MasoodFrans J Th Wackers
Jan 11, 2003·The American Journal of Cardiology·George Allan Beller
Apr 13, 1995·The American Journal of Cardiology·S Kaul
May 1, 1995·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·T M BatemanR W Ligon
Jul 1, 1995·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·L L Johnson
Feb 10, 1998·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·F J Wackers
Aug 6, 2009·Nuclear Medicine Communications·Zekiye HasbekNergiz Hacer Turgut
Nov 18, 2003·Radiology·Vivian S LeeOrlando P Simonetti
Dec 1, 1993·The American Journal of Cardiology·C L SimekS Kaul
Jun 18, 2011·JACC. Cardiovascular Imaging·Jersey ChenBrahmajee K Nallamothu
Mar 27, 2007·American Heart Journal·Joo-Yong HahnJung Euy Park
May 16, 2008·The American Journal of the Medical Sciences·Chi-Wen ChengWen-Jin Cherng
Nov 26, 1999·Circulation·R J GibbonsA E Iskandrian
Jun 3, 1999·Circulation·R C HendelJ J Mahmarian
Jul 13, 2006·British Journal of Nursing : BJN·Louise A Danks
Jul 9, 2008·Journal of Cardiovascular Medicine·Joseph A DiamondMilena J Henzlova
May 5, 2017·Annals of Nuclear Medicine·Takayuki ShibutaniSeigo Kinuya
Mar 7, 2012·Clinical Nuclear Medicine·Punit SharmaArun Malhotra