Do feeding practices during transfusion influence the risk of developing necrotising enterocolitis in preterm infants?

Journal of Paediatrics and Child Health
Cathie Hilditch, Amy K Keir

Abstract

Our evidence-based review set out to answer the clinical question 'In a preterm infant (patient) with anaemia of prematurity, do feeding practices (intervention) during blood transfusion reduce the risk of developing transfusion-associated necrotising enterocolitis (outcome)'? We found limited evidence that withholding feeding during red blood cell transfusion in preterm infants may reduce the risk of development of transfusion-associated necrotising enterocolitis. As clinical equipoise seemingly exists, it seems reasonable for individual units to make their own decisions regarding whether to withhold or continue enteral feeds during red blood cell transfusion until further evidence is available. The UK-based Withholding Enteral Feeds Around Transfusion (WHEAT) trial, a nation-wide multi-centre 'opt-out' randomised controlled study, hopefully will definitively answer our clinical question. Further research in other areas of neonatal care, using this innovative study design, is needed and it is exciting to see such a study underway.

References

Jul 16, 2004·Heart·P JepsenH T Sørensen
Oct 10, 2006·Lancet·Patricia W Lin, Barbara J Stoll
Mar 19, 2008·Seminars in Perinatology·Patricia W LinBarbara J Stoll
Sep 27, 2008·Annual Review of Medicine·Marion C W Henry, R Lawrence Moss
Jan 7, 2010·Transfusion·Robert D ChristensenTheodore J Pysher
Oct 2, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Aaron PitzeleThomas Havranek
Sep 16, 2016·Archives of Disease in Childhood. Fetal and Neonatal Edition·C GaleUNKNOWN WHEAT trial development group

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Citations

Mar 21, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Suzan SahinMark A Underwood
Mar 7, 2021·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Leslie A ParkerMarina Magalhães

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